Peptides

Bis-Sh-Pentapeptide-5 Porphyra 334

INCI: BIS-SH-PENTAPEPTIDE-5 PORPHYRA 334

Reviewed by Emma · Last updated 2 Jun 2026

Also known as: Bis-sh-pentapeptide-5 Porphyra 334

A marine-derived UV protectant and antioxidant peptide from red algae

Best For Skin Types

All, Sensitive, Mature

Addresses

Fine lines, Dryness, Sensitivity

Usage Frequency

Daily

What Is Bis-Sh-Pentapeptide-5 Porphyra 334?

Bis-Sh-Pentapeptide-5 Porphyra 334 is a mycosporine-like amino acid (MAA) extracted from Porphyra yezoensis, a species of red algae. In nature, these compounds help algae survive intense UV exposure in marine environments. When incorporated into skincare formulations, it functions as both a UV filter and antioxidant.

The ingredient works on multiple levels: it absorbs ultraviolet radiation before it damages skin cells, and simultaneously scavenges free radicals—unstable molecules produced by UV exposure and environmental stress that contribute to skin aging.

Benefits for Your Skin

How It Works

Porphyra 334 contains chemical structures that naturally absorb UV wavelengths, converting harmful radiation into harmless heat. This mechanism is similar to how the algae protects itself in ocean conditions, and translates effectively to skincare use.

Beyond UV filtration, the ingredient reduces reactive oxygen species (ROS)—highly reactive molecules generated by UV exposure. By lowering ROS levels and supporting antioxidant enzymes like catalase, it helps prevent the oxidative stress that triggers collagen breakdown and other signs of photoaging.

Clinical Evidence & References

Laboratory studies on human skin cells demonstrate that porphyra-334 protects against UVA-induced damage, suppresses the production of matrix metalloproteinase-1 (an enzyme that breaks down collagen), and supports collagen synthesis in fibroblasts. It has also shown antioxidant effects independent of UV exposure, suggesting broader cellular protection.

The evidence base is promising but consists primarily of in-vitro and cell-culture studies. Larger human clinical trials would provide clearer insight into real-world efficacy and optimal concentrations for skincare products. Current data suggests it is a reasonably effective complementary UV and antioxidant ingredient, though not a replacement for broad-spectrum sunscreen.

How to Use

This ingredient is most commonly found in serums, moisturisers, and sun care products. Since it offers UV protection and antioxidant benefits, it is well-suited to daytime skincare routines. Use as directed by the product formulation; it works best as part of a comprehensive sun protection strategy that includes broad-spectrum sunscreen and physical protective measures.

Safety & Precautions

Porphyra 334 is derived from a natural marine source and is generally well-tolerated across skin types. No significant adverse reactions have been reported in available literature, though patch testing is advisable for those with known sensitivities to marine ingredients.

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