Dihydromyricetin

Dihydromyricetin (DHM) is a naturally occurring flavonoid found in various plants, including ampelopsis and rattan. In skincare, it functions as a skin conditioning agent with potential activity against age-related changes in the skin.Unlike ingredients that work primarily through hydration or surface effects, dihydromyricetin is proposed to work by influencing epigenetic processes—the chemical switches that control how genes are expressed without altering DNA itself. This mechanism represents an emerging area of skin aging research.

Dihydromyricetin is theorised to work by inhibiting DNMT1, an enzyme responsible for maintaining DNA methylation patterns during cell division. By modestly reducing this activity, it may help restore epigenetic patterns associated with younger skin and improve gene expression in skin cells.Additionally, DHM may function as a RAGE inhibitor, potentially blocking the effects of advanced glycation end products that accumulate with age and contribute to loss of skin elasticity and increased stiffness.

If using a product containing dihydromyricetin, incorporate it into your routine according to the specific product instructions—typically as part of a serum or treatment applied to clean skin. As research on this ingredient is still emerging, consistency over time may be important, though no specific duration has been formally established for visible results.

Dihydromyricetin is derived from natural sources and appears to have a favourable safety profile. No significant adverse effects have been reported in available research, though long-term safety data in humans remains limited.