Antioxidant

Dihydroquercetin Glucoside

INCI: DIHYDROQUERCETIN GLUCOSIDE

Reviewed by Kate · Last updated 2 Jun 2026

Also known as: Dihydroquercetin Glucoside

A plant-derived antioxidant that helps protect skin from environmental stress

Best For Skin Types

All

Addresses

Fine lines, Dryness, Environmental damage

Usage Frequency

Daily

What Is Dihydroquercetin Glucoside?

Dihydroquercetin glucoside is a flavonoid compound—a type of plant polyphenol—derived from sources such as grapes and other botanicals. It functions as an antioxidant in skincare formulations, meaning it helps neutralise free radicals that can accumulate on and in the skin from environmental exposure, UV radiation, and oxidative stress.

In cosmetic products, it serves a dual role: as an antioxidant that protects skin cells from damage, and as a skin conditioning agent that may help maintain the skin's appearance and resilience.

Benefits for Your Skin

How It Works

Dihydroquercetin glucoside operates by donating electrons to unstable free radical molecules, rendering them inert and preventing them from damaging skin cells. This process is particularly relevant in the context of UV exposure and environmental pollution, both of which generate reactive oxygen species (ROS) that can degrade collagen, impair skin barrier function, and accelerate visible signs of ageing.

As a skin conditioning agent, it may also help maintain hydration and support the skin's structural integrity, though the specific mechanism in topical formulations requires further investigation.

Clinical Evidence & References

Research on plant extracts containing flavonoids—the broader class to which dihydroquercetin glucoside belongs—suggests potential benefits in mitigating UV-induced damage. Studies on plant-derived antioxidants have shown they can help regulate matrix metalloproteinase production (enzymes that break down collagen) and support collagen expression in skin cells exposed to UV radiation.

However, direct clinical evidence specifically on dihydroquercetin glucoside in topical skincare is limited. Most existing data comes from botanical extract studies or in vitro research rather than human trials. More targeted research would help clarify its efficacy when used at typical cosmetic concentrations and delivery mechanisms.

How to Use

Dihydroquercetin glucoside is typically incorporated into serums, moisturisers, and protective products rather than used as a standalone treatment. It works well as part of a layered routine with other antioxidants (such as vitamin C or vitamin E) and broad-spectrum SPF, which together provide more comprehensive defence against environmental stressors. Apply products containing this ingredient to clean skin morning and evening, or as directed on the product label.

Safety & Precautions

Dihydroquercetin glucoside is generally well-tolerated and considered safe for topical use in cosmetic products. No significant adverse effects or cautions have been widely reported, though those with known sensitivities to botanical extracts should patch-test first.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations