Dihydroquercetin Glucoside
INCI: DIHYDROQUERCETIN GLUCOSIDE
Reviewed by Kate · Last updated 2 Jun 2026
Also known as: Dihydroquercetin Glucoside
A plant-derived antioxidant that helps protect skin from environmental stress
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Dihydroquercetin Glucoside?
Dihydroquercetin glucoside is a flavonoid compound—a type of plant polyphenol—derived from sources such as grapes and other botanicals. It functions as an antioxidant in skincare formulations, meaning it helps neutralise free radicals that can accumulate on and in the skin from environmental exposure, UV radiation, and oxidative stress.
In cosmetic products, it serves a dual role: as an antioxidant that protects skin cells from damage, and as a skin conditioning agent that may help maintain the skin's appearance and resilience.
Benefits for Your Skin
How It Works
Dihydroquercetin glucoside operates by donating electrons to unstable free radical molecules, rendering them inert and preventing them from damaging skin cells. This process is particularly relevant in the context of UV exposure and environmental pollution, both of which generate reactive oxygen species (ROS) that can degrade collagen, impair skin barrier function, and accelerate visible signs of ageing.
As a skin conditioning agent, it may also help maintain hydration and support the skin's structural integrity, though the specific mechanism in topical formulations requires further investigation.
Clinical Evidence & References
Research on plant extracts containing flavonoids—the broader class to which dihydroquercetin glucoside belongs—suggests potential benefits in mitigating UV-induced damage. Studies on plant-derived antioxidants have shown they can help regulate matrix metalloproteinase production (enzymes that break down collagen) and support collagen expression in skin cells exposed to UV radiation.
However, direct clinical evidence specifically on dihydroquercetin glucoside in topical skincare is limited. Most existing data comes from botanical extract studies or in vitro research rather than human trials. More targeted research would help clarify its efficacy when used at typical cosmetic concentrations and delivery mechanisms.
Published Research
How to Use
Dihydroquercetin glucoside is typically incorporated into serums, moisturisers, and protective products rather than used as a standalone treatment. It works well as part of a layered routine with other antioxidants (such as vitamin C or vitamin E) and broad-spectrum SPF, which together provide more comprehensive defence against environmental stressors. Apply products containing this ingredient to clean skin morning and evening, or as directed on the product label.
Safety & Precautions
Frequently Asked Questions
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