Dimethyl Sulfone
INCI: DIMETHYL SULFONE
Reviewed by Rosie · Last updated 14 Aug 2026
Also known as: Dimethyl Sulfone
A solvent and viscosity modifier with emerging evidence in skin barrier support
Best For Skin Types
All, Dry, Sensitive
Addresses
Usage Frequency
Daily
What Is Dimethyl Sulfone?
Dimethyl sulfone (also known as methylsulfonylmethane or MSM) is an organic compound commonly used in cosmetic formulations as a solvent and to adjust product texture and consistency. It appears in roughly 0.3% of skincare products on the market.
In formulations, it functions primarily to dissolve and stabilise other ingredients whilst controlling how a product feels on the skin. Beyond this technical role, some preliminary research suggests it may have a role in maintaining skin structure and barrier function, though evidence remains limited.
Benefits for Your Skin
How It Works
Dimethyl sulfone works on two levels. Technically, it dissolves and carries other skincare actives, ensuring they are evenly distributed throughout a product. This improves both efficacy and stability of formulations.
At the biological level, emerging evidence suggests it may support the skin's natural production of keratin and connective tissue proteins, which could help maintain barrier function and skin resilience. However, most current research has focused on oral supplementation rather than topical application, so the precise mechanisms in skincare remain incompletely understood.
Clinical Evidence & References
A case study documented improvements in severe ichthyosis (a rare genetic skin condition characterised by dry, thickened, scaling skin) when a topical regimen containing dimethyl sulfone was applied alongside other supporting ingredients. After four weeks, significant clearing and comfort improvement were noted.
Toxicology data in animals shows dimethyl sulfone to be well tolerated at doses considerably higher than those likely in topical products. However, dedicated human clinical trials assessing its efficacy in common skin concerns remain sparse, so claims about its skincare benefits should be viewed as preliminary.
How to Use
Dimethyl sulfone is typically a background ingredient in formulations rather than a star active, so no special usage protocol is required. Use the product as directed by the manufacturer. It is generally compatible with other skincare ingredients and does not typically require staggered application or specific timing.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Dimethicone/Bis-Isobutyl PPG-20 Crosspolymer
Synthetic cross-linked polymer
Dimethicone/Vinyl Dimethicone Crosspolymer
A type of silicone powder | Can be difficult to disperse in a formulation
Dimethyl Ether
A multifunctional solvent that supports skin barrier structure and hydration
Dimethylimidazolidinone Rice Starch
A rice starch derivative that absorbs excess oil and thickens formulations
Dipentaerythrityl Hexahydroxystearate …
A multifunctional conditioning agent that helps stabilise and smooth formulations
Dipentaerythrityl Tetrahydroxystearate/Tetraisostearate
A thickening agent and skin conditioner derived from fatty acids
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.