Texture Enhancer

Dimethyl Sulfone

INCI: DIMETHYL SULFONE

Reviewed by Rosie · Last updated 14 Aug 2026

Also known as: Dimethyl Sulfone

A solvent and viscosity modifier with emerging evidence in skin barrier support

Best For Skin Types

All, Dry, Sensitive

Addresses

Dryness, Barrier repair, Sensitivity

Usage Frequency

Daily

What Is Dimethyl Sulfone?

Dimethyl sulfone (also known as methylsulfonylmethane or MSM) is an organic compound commonly used in cosmetic formulations as a solvent and to adjust product texture and consistency. It appears in roughly 0.3% of skincare products on the market.

In formulations, it functions primarily to dissolve and stabilise other ingredients whilst controlling how a product feels on the skin. Beyond this technical role, some preliminary research suggests it may have a role in maintaining skin structure and barrier function, though evidence remains limited.

How It Works

Dimethyl sulfone works on two levels. Technically, it dissolves and carries other skincare actives, ensuring they are evenly distributed throughout a product. This improves both efficacy and stability of formulations.

At the biological level, emerging evidence suggests it may support the skin's natural production of keratin and connective tissue proteins, which could help maintain barrier function and skin resilience. However, most current research has focused on oral supplementation rather than topical application, so the precise mechanisms in skincare remain incompletely understood.

Clinical Evidence & References

A case study documented improvements in severe ichthyosis (a rare genetic skin condition characterised by dry, thickened, scaling skin) when a topical regimen containing dimethyl sulfone was applied alongside other supporting ingredients. After four weeks, significant clearing and comfort improvement were noted.

Toxicology data in animals shows dimethyl sulfone to be well tolerated at doses considerably higher than those likely in topical products. However, dedicated human clinical trials assessing its efficacy in common skin concerns remain sparse, so claims about its skincare benefits should be viewed as preliminary.

How to Use

Dimethyl sulfone is typically a background ingredient in formulations rather than a star active, so no special usage protocol is required. Use the product as directed by the manufacturer. It is generally compatible with other skincare ingredients and does not typically require staggered application or specific timing.

Safety & Precautions

Dimethyl sulfone is generally well tolerated in topical formulations and shows a favourable toxicology profile. No significant cautions have been documented for typical skincare use.

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