Best For Skin Types
All
Usage Frequency
As directed
What Is Dodecane?
Dodecane is a straight-chain alkane hydrocarbon derived from petroleum. It is a colourless, volatile liquid that functions as a solvent and carrier in cosmetic formulations.
In skincare products, dodecane is used mainly as a vehicle for fragrance compounds, helping to dissolve and distribute scent throughout a product. It appears in approximately 0.2% of skincare formulations, typically at low concentrations.
How It Works
Dodecane functions as a non-polar solvent, meaning it dissolves and distributes non-water-soluble substances, including many fragrance molecules. Once applied to skin, its volatile nature means it evaporates relatively quickly.
Because it is a hydrocarbon, it does not form chemical bonds with skin components; instead, it acts as a carrier medium that delivers other actives or fragrances and then disperses.
Clinical Evidence & References
Research on dodecane's dermal effects is limited in the context of cosmetic use. Animal studies examining prolonged or high-level occupational exposure (relevant to industrial settings rather than skincare application) have shown variable irritation responses depending on exposure duration and concentration.
At the low concentrations typical in skincare products, dodecane is not expected to pose significant concerns for most users. However, evidence specifically evaluating its safety in cosmetic formulations at these concentrations is sparse, so individual sensitivity remains possible.
Published Research
How to Use
Dodecane-containing products can be used as directed on the label. Because it is volatile, products containing it should be stored with lids firmly closed to prevent ingredient loss over time. If fragrance sensitivity is a concern, patch-test before full application.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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Dihydro-Alpha-Methyl Alpha-Ionone
A fragrance compound with emerging research into skin protection and resilience
Dimethylhydroquinone
A fragrance component with potential antioxidant properties in skincare formulations
Dipteryx Odorata Bean Extract
A natural fragrance ingredient derived from tonka bean with sensory masking properties
Ethyl Butyrate
A fragrant compound used primarily to enhance the scent profile of skincare formulations
Ethyl Dimethyl-Methylenecyclohexenecarboxylate
A synthetic fragrance component used to add scent to skincare formulations
Ethyl Formate
A volatile fragrance component that adds scent to skincare formulations
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