Endonuclease V
INCI: ENDONUCLEASE V
Reviewed by Rosie · Last updated 2 Jun 2026
A DNA repair enzyme being investigated for potential sun damage prevention
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Endonuclease V?
Endonuclease V is an enzyme derived from bacteriophages (viruses that infect bacteria) that has been studied for its potential role in supporting skin protection. The enzyme functions by recognising and addressing certain types of DNA damage, specifically the kind induced by ultraviolet radiation exposure.
In skincare formulations, endonuclease V is positioned as a protective ingredient designed to work alongside conventional sun protection strategies, though its use in cosmetics remains relatively novel and evidence-based understanding is still developing.
How It Works
Endonuclease V works by identifying abnormal DNA structures created when ultraviolet radiation damages skin cells. The enzyme recognises these damaged sections and facilitates their removal, allowing the skin's own repair machinery to work more effectively.
This mechanism is particularly relevant because certain genetic conditions—such as xeroderma pigmentosum—involve impaired DNA repair following sun exposure. Research has explored whether endonuclease V might provide a compensatory function in such cases, though its application in regular skincare formulations is still being evaluated.
Clinical Evidence & References
Research into endonuclease V has primarily focused on its potential in managing genetic disorders affecting DNA repair. Studies suggest the enzyme can recognise and facilitate the removal of UV-induced DNA damage, which forms the theoretical basis for its use in skincare.
However, evidence for its effectiveness in standard cosmetic formulations remains limited. Most published research concentrates on therapeutic applications rather than preventive skincare use. Additional clinical trials in typical skincare contexts would help clarify its practical benefit as part of a sun protection regimen.
How to Use
Endonuclease V should be considered a complementary ingredient rather than a replacement for established sun protection measures. Use it as part of a comprehensive approach that includes daily broad-spectrum sunscreen (SPF 30 or higher), protective clothing, and sun-avoidance during peak UV hours. Follow product instructions for application order and frequency, typically incorporating it into your morning routine before sunscreen application.
Safety & Precautions
Frequently Asked Questions
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