Genistein
Reviewed by Emma · Last updated 18 Aug 2026
Belongs to a set of compounds known as isoflavones, which are sources of phytoestrogens Commonly derived from soy
EWG Safety Score
What Is Genistein?
Genistein is a naturally occurring plant ingredient that belongs to a group of compounds known as isoflavones. Isoflavones are sources of phytoestrogens, also known as plant estrogens, that are not hormones but can connect with receptor sites on skin’s surface, helping it look and feel younger. Genistein is most often derived from soy but can also be produced synthetically (’s Choice Skincare uses the natural variety).
As an isoflavone, genistein is a rich source of antioxidants that have impressive skin-soothing properties. Research shows that genistein has multiple benefits for skin, both when it’s ingested and used topically. Applied to skin, genistein exhibits anti-ageing effects, including reducing the visible appearance of wrinkles and helping protect skin from the effects of sun damage.
It penetrates skin better than “sister” isoflavone daidzein, but research has shown that these ingredients work even better when paired in a single formula. This is due to the synergy they share as well as both having an affinity for key receptor sites on skin’s surface.
Emerging studies also show genistein has a special ability to improve signs of ageing and dry skin that are common during menopause. It is typically used in amounts of 0.251% for these benefits, although studies have been done looking at concentrations up to 4%.
Clinical Evidence & References
- Phytotherapy Research, March 2020, Volume 34, Issue 3, pages 435-447
- Surgical and Cosmetic Dermatology, March 2020
- International Journal of Women’s Dermatology, June 2019, pages 85-90
- AAPS FarmSciTech, October 2018, Issue 19, Volume 7, pages 3029-3,039
- Nutrients, June 2017, Volume 9, Issue 6, page 622
- Journal of Photochemistry and Photobiology B: Biology, March 2015, pages 20-27
- International Journal of Pharmaceutics, November 2008, pages 36-44
- The Journal of Nutrition, November 2003, Volume 133, Issue 11, pages 3811S–3819S
- Journal of Investigative Dermatology, May 2003, pages 835-841
Frequently Asked Questions
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Daidzein
A type of antioxidant known as an isoflavone found in soybeans Pronounced ability to help skin better withstand environmental exposure
Soy Oil
Soy oil is a non-fragrant plant oil with multiple uses for skin
Garcinia Mangostana Peel Extract
Comes from mangosteen, a fruit native to Asia Rich source of xanthones, natural polyphenolic compounds
Gardenia Jasminoides Meristem Cell Culture
Plant cell culture extract with antioxidant properties for protective skincare
Gardenia Taitensis Callus Extract
Plant-derived antioxidant extract that helps shield skin from environmental stress
Genistein Glucoside
A plant-derived antioxidant with emerging research into skin conditioning and pigmentation
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