Ginsenoside Re
INCI: GINSENOSIDE RE
Reviewed by Kate · Last updated 14 Aug 2026
Also known as: Ginsenoside Re
A ginseng extract with antioxidant and barrier-supporting properties
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Ginsenoside Re?
Ginsenoside Re is a saponin compound extracted from various parts of the ginseng plant, including roots, leaves, berries, and flowers. It is one of the primary active constituents of ginseng and has been studied for its potential effects on skin health and resilience.
In skincare formulations, ginsenoside Re functions as an antioxidant, humectant, and skin conditioning agent. It works to help protect skin from oxidative stress whilst also supporting the skin's natural moisture retention and barrier function.
Benefits for Your Skin
How It Works
Ginsenoside Re appears to work through multiple pathways. Its antioxidant activity involves supporting the skin's glutathione metabolism—a key system for neutralising harmful free radicals and protecting cells from oxidative damage, particularly from UV exposure.
In terms of barrier function, research in keratinocytes suggests ginsenoside Re may upregulate filaggrin and caspase-14, proteins involved in the formation and maintenance of the skin's outermost protective layer, known as the cornified envelope. This support for barrier integrity may help reduce transepidermal water loss and improve overall skin resilience.
Clinical Evidence & References
Research into ginsenoside Re is still emerging. In laboratory studies using keratinocyte models, ginsenoside Re demonstrated the ability to strengthen the skin barrier and support normal barrier function under standard conditions. Animal studies have suggested it may protect against UVB-induced skin damage through antioxidant and anti-inflammatory mechanisms.
However, clinical trials directly evaluating its effects in human skin are limited, so evidence for real-world efficacy in topical formulations remains preliminary. Further human studies would help clarify its practical benefits when applied to skin.
Published Research
How to Use
Ginsenoside Re is typically found in serums, toners, essences, and moisturisers. It can be used daily as part of a routine; since it is a gentle, plant-derived ingredient, it generally integrates well with other skincare actives. For those new to ginseng extracts, introducing the product gradually allows you to assess individual tolerance.
Safety & Precautions
Frequently Asked Questions
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