Glycyrrhiza Uralensis Root Prenylflavonoids
INCI: GLYCYRRHIZA URALENSIS ROOT PRENYLFLAVONOIDS
Reviewed by Rosie · Last updated 14 Aug 2026
A plant-derived compound that helps condition and support skin's natural resilience
Best For Skin Types
All, Sensitive, Mature
Addresses
Usage Frequency
Daily
What Is Glycyrrhiza Uralensis Root Prenylflavonoids?
Glycyrrhiza uralensis root prenylflavonoids are bioactive compounds extracted from the root of Uralian liquorice, a plant native to Central Asia. Prenylflavonoids are a specific class of flavonoid molecules characterised by the presence of a prenyl group, which enhances their ability to penetrate and interact with skin tissue.
In skincare formulations, these prenylflavonoids function primarily as skin conditioning agents, working to support the skin's moisture retention and structural integrity. They are typically incorporated into serums, moisturisers and treatment products where their antioxidant and anti-inflammatory properties may complement a broader skincare routine.
How It Works
Prenylflavonoids work through multiple pathways. Their antioxidant activity neutralises free radicals that can degrade collagen and elastin, whilst their anti-inflammatory action may reduce localised redness and irritation. The prenyl substituent on these molecules makes them more lipophilic, allowing them to penetrate the skin more effectively than non-prenylated flavonoids.
Additionally, these compounds support the skin's barrier function by conditioning keratin and promoting natural hydration mechanisms, helping skin maintain its protective function and appearance.
Clinical Evidence & References
Research on Glycyrrhiza uralensis prenylflavonoids specifically is limited in peer-reviewed literature. However, liquorice root compounds more broadly have a well-documented history in both traditional and modern skincare, with evidence supporting their antioxidant and soothing properties.
The prenylflavonoid fraction is considered a refined, more bioavailable form of liquorice's active constituents. Whilst mechanistic studies suggest these compounds should offer meaningful benefits, clinical efficacy studies specific to the prenylflavonoid form remain sparse. Inclusion in formulations is typically based on traditional use and in vitro research rather than extensive human trials.
How to Use
These ingredients are best used as part of a layered skincare routine. Apply serums or treatments containing prenylflavonoids to clean skin before your moisturiser. Because they work best when the skin is adequately hydrated, pair them with a good hydrating moisturiser. Use consistently to notice conditioning and protective benefits over time, though results are typically subtle and gradual rather than immediate.
Safety & Precautions
Frequently Asked Questions
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