Heptasodium Hexacarboxymethyl Dipeptide-12
INCI: HEPTASODIUM HEXACARBOXYMETHYL DIPEPTIDE-12
Reviewed by Emma · Last updated 14 Aug 2026
Also known as: Heptasodium Hexacarboxymethyl Dipeptide-12
A peptide-derived ingredient that activates cellular renewal pathways to address visible signs of ageing
Best For Skin Types
All, Mature
Addresses
Usage Frequency
Daily
What Is Heptasodium Hexacarboxymethyl Dipeptide-12?
Heptasodium hexacarboxymethyl dipeptide-12 is a synthetic peptide compound designed to support skin's natural renewal processes. It functions as a skin conditioning agent and is formulated to work at the cellular level rather than through surface effects alone.
This ingredient was developed to target cellular senescence—the process by which skin cells lose their ability to function optimally—particularly in response to environmental stressors such as UV exposure. By engaging specific cellular pathways, it aims to support skin health and appearance over time.
How It Works
This ingredient works by activating SIRT1, a protein involved in cellular maintenance and stress response. When SIRT1 is activated, it triggers autophagy—a cellular housekeeping process where the skin cell identifies and removes damaged or dysfunctional components. This keeps cells functioning more efficiently and may slow the accumulation of age-related changes.
Additionally, the ingredient demonstrates antioxidant properties, helping to neutralise free radicals that accumulate from sun exposure and environmental pollution. Together, these mechanisms aim to support healthier, more resilient skin from within.
Clinical Evidence & References
In vitro studies show that this ingredient activates SIRT1 and stimulates autophagy in human skin cells. A randomised, placebo-controlled clinical trial evaluated its topical use and found antioxidant effects, including a measurable reduction in oxidative damage markers in the outer layer of skin.
Whilst these findings are encouraging, the clinical evidence base is still emerging. More extensive studies would help clarify the magnitude of anti-ageing effects in real-world use and optimal formulation concentrations. Current evidence suggests potential benefits, though results may be gradual and best observed with consistent use over several weeks.
How to Use
This ingredient is typically found in serums, moisturisers and treatments. For best results, use consistently as directed by your chosen product. As with any active ingredient, introduce it gradually into your routine to assess tolerance. It pairs well with sun protection, which will enhance its benefits by reducing new UV-induced cellular damage.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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