Hydrolyzed Glycyrrhizinate
INCI: HYDROLYZED GLYCYRRHIZINATE
Reviewed by Kate · Last updated 14 Aug 2026
A licorice-derived ingredient that conditions and helps calm reactive skin
Best For Skin Types
All, Sensitive
Addresses
Effective Concentrations
Up to 1%
Usage Frequency
Daily
What Is Hydrolyzed Glycyrrhizinate?
Hydrolyzed glycyrrhizinate is a processed form of glycyrrhizin, a compound naturally present in licorice root. It functions as a skin conditioning agent, helping to improve the overall feel and appearance of the skin. The hydrolysis process breaks down the parent compound into a more stable form suitable for use in topical skincare formulations.
This ingredient works at the surface level to support skin conditioning, making it a common inclusion in products designed for sensitive or reactive skin types.
How It Works
Hydrolyzed glycyrrhizinate conditions the skin by coating and smoothing the outer layer, which can reduce the appearance of dryness and irritation. The ingredient's soothing properties are thought to stem from the anti-inflammatory potential of its parent compound, glycyrrhizin.
When applied topically, it may help modulate inflammatory responses in the skin, though the extent of this effect in typical cosmetic concentrations is not yet fully characterised in clinical settings.
Clinical Evidence & References
Research on glycyrrhizin and its derivatives suggests anti-inflammatory potential, particularly in cell-based studies. However, most robust evidence focuses on higher concentrations or the parent compound rather than the hydrolyzed form used in cosmetics.
In typical skincare formulations, hydrolyzed glycyrrhizinate is used at relatively low concentrations, and direct clinical evidence of efficacy at these levels remains limited. It is generally considered safe for topical use based on ingredient safety assessments, but claims about specific skin benefits should be regarded as preliminary pending further human studies.
Published Research
How to Use
Hydrolyzed glycyrrhizinate is typically found as a supporting ingredient in serums, moisturisers, and soothing products rather than as a star active. It can be used daily as part of your routine, and pairs well with other skin-conditioning ingredients. No special application technique is required.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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