Antioxidant

Hydrolyzed Proanthocyanidin

INCI: HYDROLYZED PROANTHOCYANIDIN

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Hydrolyzed Proanthocyanidin

A plant-derived polyphenol that helps protect skin from oxidative stress

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Oxidative stress, Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Hydrolyzed Proanthocyanidin?

Hydrolyzed proanthocyanidin is a polyphenolic compound derived from plant sources such as pomegranate, sorghum, and camu-camu fruit. It belongs to a class of flavonoids known for their antioxidant properties. The hydrolyzed form means the larger molecular structures have been broken down into smaller units, potentially improving skin penetration and bioavailability.

In skincare formulations, hydrolyzed proanthocyanidin functions as an antioxidant to neutralise free radicals, whilst also providing emollient and humectant properties that support skin hydration and barrier health.

Benefits for Your Skin

How It Works

Hydrolyzed proanthocyanidins work primarily through free radical scavenging. Free radicals are unstable molecules generated by UV exposure, pollution, and natural cellular processes. These compounds donate electrons to stabilise free radicals, preventing them from damaging skin cells and collagen.

The humectant and emollient properties operate through different mechanisms: humectants absorb water from the environment and deeper skin layers to plump the outer layer, whilst emollients form a lightweight protective film that reduces transepidermal water loss.

Clinical Evidence & References

Research indicates that proanthocyanidins from various plant sources demonstrate antioxidant activity in laboratory settings. Studies on pomegranate, sorghum, and camu-camu extracts rich in these compounds show they can scavenge multiple types of free radicals and chelate metal ions that contribute to oxidative damage.

However, most evidence comes from in vitro studies. Human clinical data on hydrolyzed proanthocyanidin specifically in skincare formulations is limited, so efficacy in real-world use warrants further investigation. The concentration and stability of the ingredient in finished products may influence its effectiveness.

How to Use

Hydrolyzed proanthocyanidin is typically used in serums, moisturisers, and treatment products at concentrations that support antioxidant and conditioning benefits. It works well alongside other antioxidants such as vitamin E or vitamin C, though formulation chemistry should be considered to ensure stability. Use daily as part of your routine for consistent protective benefits.

Safety & Precautions

Generally well-tolerated and suitable for most skin types. As with any ingredient, perform a patch test if you have known sensitivities to plant-derived polyphenols.

Frequently Asked Questions

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