Hydrolyzed Sodium Dna
INCI: HYDROLYZED SODIUM DNA
Reviewed by Rosie · Last updated 2 Jun 2026
A DNA-derived conditioning agent that supports skin's structural integrity
Best For Skin Types
All, Dry, Sensitive, Mature
Addresses
Usage Frequency
Daily
What Is Hydrolyzed Sodium Dna?
Hydrolyzed sodium DNA is a skin conditioning ingredient derived from deoxyribonucleic acid (DNA) that has been broken down into smaller fragments. This process makes it suitable for topical application, allowing the molecule to interact with the skin's outer layers rather than penetrate deeply.
In skincare formulations, it functions as a humectant and conditioning agent, helping to maintain moisture levels and support the skin barrier's overall health and resilience.
How It Works
Hydrolyzed sodium DNA works primarily through its humectant properties. Its molecular structure allows it to bind water molecules and hold them within the skin, which can help improve hydration and reduce transepidermal water loss (TEWL). This mechanism is similar to other humectants used in skincare, such as glycerol or hyaluronic acid.
By maintaining adequate moisture levels, the ingredient indirectly supports barrier function and skin comfort, though it does not actively repair or rebuild skin structures on a biochemical level.
Clinical Evidence & References
Research on hydrolyzed DNA in skincare is limited compared to more established conditioning agents. Available evidence suggests the ingredient performs a standard humectant role, supporting hydration and skin conditioning, though robust clinical data demonstrating specific or superior efficacy remains modest.
The ingredient's inclusion in formulations is generally considered safe and suitable for routine use, but consumers should not expect transformative results beyond basic moisturising and conditioning benefits.
How to Use
Hydrolyzed sodium DNA is typically found in moisturisers, serums, and hydrating treatments. For best results, apply to clean, damp skin and follow with an occlusive moisturiser to seal in hydration. It works well alongside other humectants and hydrating ingredients.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Hydrolyzed Salmon Ovary Membrane Extract
A marine-derived conditioning agent that supports skin hydration and texture
Hydrolyzed Silk Pg-Propyl Methylsilanediol
A silicone-silk hybrid that conditions and smooths both skin and hair
Hydrolyzed Snail Body Extract
A protein-rich extract that may help support skin hydration and comfort
Hydrolyzed Soy Flour
Derived from soybeans | Used as a skin conditioning ingredient
Hydrolyzed Soybean Seed
Plant-derived protein that conditions and supports skin's moisture retention
Hydrolyzed Sponge
A marine-derived conditioning agent that supports skin hydration and texture
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.