Hydroxypropyltrimonium Hydrolyzed Keratin
INCI: HYDROXYPROPYLTRIMONIUM HYDROLYZED KERATIN
Reviewed by Kate · Last updated 14 Aug 2026
A conditioning polymer derived from keratin that helps strengthen and smooth hair and skin
Best For Skin Types
All, Dry, Sensitive
Addresses
Usage Frequency
Daily
What Is Hydroxypropyltrimonium Hydrolyzed Keratin?
Hydroxypropyltrimonium hydrolyzed keratin is a modified form of keratin, the structural protein found naturally in hair and skin. It is created by breaking down keratin into smaller fragments and then chemically modifying it with a positively charged group (quaternary ammonium). This makes it soluble in water and able to form a thin, protective layer on skin and hair surfaces.
In skincare products, this ingredient functions as both a conditioning and antistatic agent, helping to improve texture and reduce friction on the skin's surface.
How It Works
The positively charged nature of this ingredient allows it to bind to the negatively charged surface of skin cells. Once bound, it deposits a thin, occlusive layer that helps reduce water loss and creates a smoother surface feel.
Because it is derived from keratin, which is chemically similar to natural skin proteins, it integrates relatively well with the skin's own structure, potentially offering some conditioning benefit beyond simple surface coating.
Clinical Evidence & References
Direct clinical research specifically on hydroxypropyltrimonium hydrolyzed keratin in skincare is limited. Most evidence for this ingredient comes from cosmetic chemistry research and manufacturer data rather than published clinical trials on human skin.
It is well-established that quaternary ammonium-modified polymers function effectively as conditioning and antistatic agents in personal care formulations. Whether keratin-based versions offer additional benefits over synthetic polymers remains unclear in the published literature.
How to Use
This ingredient is typically used in cleansers, conditioners, and leave-on skincare products where its conditioning effect can be felt immediately. It works alongside other humectants and emollients; there is no specific timing or sequencing requirement. Use as directed by the product formulation.
Safety & Precautions
Frequently Asked Questions
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