Skin Conditioning

Inonotus Obliquus Extract

INCI: INONOTUS OBLIQUUS EXTRACT

Reviewed by Kate · Last updated 2 Jun 2026

A fungal extract with antioxidant properties traditionally used in skincare formulations

Best For Skin Types

All, Mature, Dry

Addresses

Fine lines, Dryness, Hydration

Effective Concentrations

59-70% (in extract form)

Usage Frequency

Daily

What Is Inonotus Obliquus Extract?

Inonotus obliquus extract is derived from a medicinal fungus that grows on birch trees in northern regions. The extract is rich in polysaccharides, polyphenols, and triterpenes — compounds that have been studied for their potential antioxidant and skin-conditioning properties.

In skincare formulations, it functions primarily as a skin conditioner, typically used at concentrations between 59% and 70% in extract form, though it appears in only a small proportion of commercial skincare products.

How It Works

The extract's proposed mechanisms centre on its bioactive compounds. The polysaccharide-rich fraction appears to inhibit the formation of advanced glycation end products (AGEs) — harmful compounds formed when proteins and sugars interact, which contribute to skin ageing and reduced elasticity. The polyphenols and other antioxidant compounds work by scavenging free radicals that would otherwise damage skin cell structures and proteins.

Additionally, the extract may support skin barrier function and help reduce the activity of enzymes (such as matrix metalloproteinases) that break down collagen and other structural proteins in the skin.

Clinical Evidence & References

Research on Inonotus obliquus extract in skincare remains limited. Laboratory studies demonstrate that the extract contains polysaccharides and polyphenols with measurable antioxidant capacity and the ability to inhibit AGE formation in skin cells in vitro. One study showed the extract reduced inflammatory markers and MMP enzyme activity in fibroblasts exposed to glycation stress, suggesting potential benefits for skin elasticity and firmness.

However, human clinical studies are sparse. The evidence base is strongest for the extract's antioxidant and AGE-inhibiting properties at a cellular level, but translation to visible skin improvements in living subjects remains to be established more thoroughly. It is generally well-tolerated, though individual sensitivity varies.

How to Use

Inonotus obliquus extract is most commonly found in serums, essences, and hydrating products rather than as a standalone treatment. When using products containing this ingredient, apply to clean skin before heavier creams or oils to allow adequate absorption. It can be used daily as part of your regular routine and combines well with other antioxidant ingredients and humectants.

Safety & Precautions

Inonotus obliquus extract is generally well-tolerated and considered safe for topical use. Those with known sensitivities to fungi or mushroom-derived ingredients should perform a patch test before use.

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