Humectant

Isopropylideneglycerol

INCI: ISOPROPYLIDENEGLYCEROL

Reviewed by Daisy · Last updated 14 Aug 2026

A humectant glycerol derivative that supports skin hydration and moisture retention

Best For Skin Types

All, Dry, Combination, Mature

Addresses

Dryness, Hydration, Barrier repair

Usage Frequency

Daily

What Is Isopropylideneglycerol?

Isopropylideneglycerol is a humectant—a type of ingredient that draws moisture into the skin from the surrounding environment and deeper skin layers. It is a modified form of glycerol, a naturally occurring compound, and functions as a water-binding agent in skincare formulations.

In products, it works to increase skin hydration levels and help maintain moisture balance. It is often included in moisturisers, serums, and hydrating treatments where supporting the skin's water content is a priority.

How It Works

Isopropylideneglycerol functions as a hygroscopic agent, meaning it has an affinity for water molecules. When applied to skin, it attracts moisture from the dermis (deeper skin layer) and the environment, pulling it into the outer layers of the epidermis.

This process hydrates the stratum corneum—the skin's outermost layer—which can improve barrier function and skin comfort. Unlike occlusive ingredients that seal moisture in, humectants work by actively drawing water into the skin, making them particularly useful in formulations designed for hydration rather than barrier occlusion alone.

Clinical Evidence & References

Research specifically examining isopropylideneglycerol in isolation is limited in published literature. However, glycerol and related humectants have been well-studied and shown to improve skin hydration, increase skin moisture content, and support barrier function when used in appropriate concentrations.

Because isopropylideneglycerol is a glycerol derivative, it is reasonable to expect similar hydrating properties, though individual product formulation, concentration, and vehicle will influence its efficacy. More targeted clinical data on this specific ingredient would help establish its precise benefits.

How to Use

Isopropylideneglycerol is typically found in leave-on products such as moisturisers, serums, and hydrating essences. Apply to clean, slightly damp skin for optimal hydration—the presence of water allows humectants to work more effectively. It can be used daily as part of your routine and pairs well with occlusive ingredients (like oils or butters) to seal in moisture.

Safety & Precautions

Isopropylideneglycerol is generally well-tolerated and considered safe for topical use in cosmetics. It is unlikely to cause irritation in most people, though those with known sensitivities to glycerol or related compounds should patch-test first.

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