Isostearyl Neopentanoate
INCI: Propanoic acid
Reviewed by Rosie · Last updated 18 Aug 2026
Also known as: Propanoic acid, 2, 2-dimethyl-, isooctadecyl ester, Ceraphyl 375, Dermol 185, Crodamol ISNP, Isooctadecyl pivalate, 2-Dimethylpropanoic Acid
Ester of isostearyl alcohol and neopentanoic acid
EWG Safety Score
What Is Isostearyl Neopentanoate?
Isostearyl neopentanoate is the ester of the fatty alcohol isostearyl alcohol and the carboxylic acid neopentanoic acid. Its listed cosmetic functions include emollient and binding agent. It can also function as a solvent for certain UV absorbers.
Isostearyl neopentanoate is noted in research for contributing lubricity and helping skin care formulations, such as moisturizers and sunscreens, spread more easily. Another benefit is that it helps skin retain moisture but doesn't add a greasy feel. In its role as a binding agent, isostearyl neopentanoate can help hold pressed powder makeup (such as eye shadow, blush, etc.) together without losing the powder-like texture.
Isostearyl neopentanoate is a clear, slightly yellow liquid in raw material form. The Cosmetic Ingredient Review Expert Panel 2015 assessment of isostearyl neopentanoate deemed it is safe in the practices of use/concentrations (up to 50%) described in their report. It may be animal-derived or synthetic.
Clinical Evidence & References
Published Research
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CosmeticsInfo.org, Accessed December 2022, ePublication CosmeticsInfo.org, 2022
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International Journal of Toxicology, 2015, page 5S-69S International Journal of Toxicology, 2015
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Handbook of Cosmetic Science and Technology, 2001, page 153 Handbook of Cosmetic Science and Technology, 2001
From the Clinic
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Isotridecyl Isononanoate
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