Lactobacillus Ferment Lysate
INCI: bulgaricus
Reviewed by Emma · Last updated 5 Aug 2026
Also known as: bulgaricus, helveticus, plantarum, casei, rhamnosus, acidophillus
Fermented byproduct of the probiotic Lactobacillus Delivers skin-soothing properties
EWG Safety Score
What Is Lactobacillus Ferment Lysate?
Lactobacillus ferment lysate is extolled for delivering a pronounced soothing effect on skin. Studies also suggest that it plays a role in helping reinforce skin's microbiome and thereby may reduce the severity of common skin conditions. The Personal Care Products Council classifies it as a skin-conditioning agent. Lactobacillus ferment lysate is a lab-created byproduct of the probiotic Lactobacillus. As it is converted into the lysate form, the outer membrane is broken down and it is no longer a living microorganism. This allows it to function more like a postbiotic, which can be safely and effectively incorporated into cosmetic formulations to replenish skin via microbiome support.
Lactobacillus ferment lysate may also be used to ferment other skin care ingredients, such as plant extracts, to enhance their benefits (the fermentation process releases skin-friendly compounds and helps make them more bioavailable). In raw material form, Lactobacillus ferment lysate appears as a cloudy, yellowish-white liquid.
It is important to note that further independent studies are needed to draw more definitive conclusions Lactobacillus ferment lysate's benefits for skin, but at the time of this writing, what exists looks promising. Of note, emerging studies (funded by ingredient suppliers) show potential for Lactobacillus ferment lysate's ability to prevent and treat visible signs of skin photoageing.
Lactobacillus ferment lysate is also marketed by a few suppliers. Because the Lactobacillus genus is non-pathogenic, the INCI names do not include the species of Lactobacillus that is being used for the fermentation product. Some of the species used are bulgaricus, helveticus, plantarum, casei, rhamnosus and acidophillus. Therefore, the different Lactobacillus ferment lysates may have very different effects on the skin.
Clinical Evidence & References
- Current Issues in Molecular Biology, January 2024, pages 513-526
- Microorganisms, July 2023, pages 1-24
- International Journal of Cosmetic Science, February 2023, pages 83-94
- Journal of the Korean Society of Cosmetology, April 2021, pages 356-363
- Molecules, March 2021, pages 1-11
- Journal of the Society of Cosmetic Scientists of Korea, 2020, pages 23-29
- International Journal of Cosmetic Science, September 2019, ePublication
Frequently Asked Questions
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