Lapachone

Lapachone is a naphthoquinone, a type of organic compound extracted from the bark of the lapacho tree. It exists in two main forms: α-lapachone and β-lapachone. In skincare, it is primarily valued for properties that may support the skin's natural repair processes.The compound has been traditionally associated with various biological activities, and contemporary research has begun to investigate its potential application in formulations designed to support wound healing and skin recovery.

Lapachone appears to support skin repair through multiple mechanisms. Research suggests it may upregulate Sirt3, a protein involved in cellular energy regulation and stress response. This activation may encourage migration of skin cells and promote angiogenesis — the formation of new blood vessels — which is essential for delivering oxygen and nutrients to healing tissue.The compound's quinone structure gives it antioxidant and antimicrobial properties, which may help create an environment conducive to faster tissue regeneration. However, the precise mechanisms in human skin remain incomple…

Lapachone is typically incorporated into creams, serums or ointments designed to support healing. As a supporting ingredient rather than a standalone active, it works best as part of a formulation that includes other evidence-backed repair ingredients. Use as directed by the product instructions, and if applying to compromised or broken skin, ensure the formulation is appropriate for that use case.

Limited safety data exists for topical use in humans. The ingredient appears generally well-tolerated in pre-clinical studies, though human safety data is sparse. Discontinue use if irritation occurs, and avoid application to severely damaged skin without medical guidance.