Humectant

Ligninase

INCI: LIGNINASE

Reviewed by Daisy · Last updated 14 Aug 2026

An enzyme-derived humectant that helps skin retain moisture

Best For Skin Types

All, Dry, Sensitive

Addresses

Dryness, Hydration

Usage Frequency

Daily

What Is Ligninase?

Ligninase is an enzyme derived from fungal or bacterial sources, used in skincare formulations primarily for its humectant properties. It works by helping the skin bind and retain water, supporting the skin's natural moisture balance.

As a naturally sourced ingredient, ligninase appeals to formulators seeking alternatives to synthetic humectants, though its use in cosmetics remains relatively niche compared to more established moisture-binding agents.

How It Works

Ligninase functions as a humectant by attracting water molecules and facilitating their binding within the outer layers of the skin. This helps reduce transepidermal water loss (TEWL) and maintain skin hydration throughout the day.

The enzyme's structure allows it to interact with the skin's natural moisture-retention factors, potentially working synergistically with the skin's own hydration pathways.

Clinical Evidence & References

Research specifically examining ligninase in skincare formulations is limited. Most evidence for its benefits comes from ingredient supplier data and small-scale cosmetic studies rather than large-scale clinical trials published in peer-reviewed journals.

Whilst humectants in general are well-documented for their hydrating effects, the specific efficacy and stability of ligninase in skin formulations would benefit from further independent investigation to establish its performance relative to more conventional humectants like glycerin or hyaluronic acid.

How to Use

Ligninase is typically found as part of a broader formulation rather than as a standalone active, so follow the product instructions for your specific skincare item. For best results, apply to damp skin to maximise its moisture-binding effects, and layer with other hydrating products if your skin needs additional support.

Safety & Precautions

Ligninase is generally well-tolerated and considered safe for topical use. As with any ingredient, discontinue use if irritation occurs.

Frequently Asked Questions

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