Anti-Sebum

Menaquinone-7

INCI: MENAQUINONE-7

Reviewed by Emma · Last updated 14 Aug 2026

A form of vitamin K that may support skin protection and sebum regulation

Best For Skin Types

All, Oily, Combination

Addresses

Oil control

Usage Frequency

Daily

What Is Menaquinone-7?

Menaquinone-7 (MK-7) is a naturally occurring form of vitamin K, a fat-soluble micronutrient found in fermented foods and produced by certain bacteria. In skincare formulations, it functions as a skin-protecting agent with reported astringent and sebum-regulating properties.

Vitamin K plays a role in various physiological processes, including protein synthesis and cellular signalling. When applied topically, menaquinone-7 is thought to influence skin behaviour through these mechanisms, though the exact pathways in cosmetic use remain an area of ongoing investigation.

How It Works

Menaquinone-7 is believed to work through multiple pathways. As a form of vitamin K, it participates in protein synthesis and cellular signalling processes that may influence sebaceous gland activity and skin barrier function.

The astringent effect is thought to result from the ingredient's interaction with skin proteins, potentially creating a subtle tightening sensation. However, the exact mechanisms of topical menaquinone-7 in cosmetic formulations are not fully characterised, and further research would help clarify its precise mode of action on skin.

Clinical Evidence & References

Evidence for menaquinone-7 in skincare is limited. Most published research examines vitamin K supplementation systemically (oral intake) rather than topical application, and focuses on medical conditions such as bone health and blood coagulation rather than cosmetic skin benefits.

Available data suggests that topical vitamin K may support skin health and potentially address oiliness, but robust clinical trials specifically investigating menaquinone-7 in skincare products are scarce. Claims regarding its efficacy should be approached with appropriate caution until further evidence accumulates.

How to Use

Menaquinone-7 is typically included in serums, moisturisers and targeted treatments. Use according to product instructions, generally applied to clean skin once or twice daily. It can be layered with other skincare ingredients, though as with any new product, introduce it gradually to monitor skin response.

Safety & Precautions

Menaquinone-7 is generally well-tolerated in cosmetic formulations. Those taking anticoagulant medications (such as warfarin) should consult a healthcare provider before using vitamin K-containing skincare products, though topical application poses minimal systemic risk.

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