Neomycin

Neomycin is a broad-spectrum antibiotic belonging to the aminoglycoside class. It is derived from the bacterium Streptomyces fradiae and works by inhibiting bacterial protein synthesis, making it effective against a range of gram-positive and gram-negative bacteria commonly found in skin infections.In skincare and dermatological products, neomycin is primarily used in topical formulations to prevent or treat bacterial infections of the skin and support the wound healing process. It is often found in first-aid products, medicated creams, and clinical skincare designed for compromised or inju…

Neomycin functions by binding to bacterial ribosomes and disrupting protein synthesis, which prevents bacteria from multiplying and causes cell death. This mechanism makes it effective against many common skin pathogens, including Staphylococcus aureus—a bacterium frequently involved in skin infections and wound complications.In formulated products, neomycin is typically stabilised within delivery systems (such as hydrogels or creams) to ensure it remains active at the skin surface where bacteria reside. The ingredient works locally at the site of application with minimal penetration into d…

Neomycin-containing products should be used as directed by the product instructions or healthcare professional guidance. For minor cuts or scrapes, apply a thin layer to clean, dry skin and cover if necessary. Avoid using on large areas of damaged skin without professional advice. Discontinue use and seek medical attention if signs of infection worsen or persist beyond a few days. Do not use preventatively on intact, healthy skin as this may contribute to bacterial resistance.

Neomycin is generally well-tolerated when used topically as directed. However, some individuals may develop contact dermatitis or sensitisation with repeated use, particularly those with a history of antibiotic sensitivity. Avoid contact with eyes and do not apply to deep wounds or puncture injuries without medical assessment.