Skin Conditioning

Paeonia Lactiflora Root Extract

INCI: PAEONIA LACTIFLORA ROOT EXTRACT

Reviewed by Daisy · Last updated 2 Jun 2026

A plant extract traditionally used to support skin conditioning and barrier function

Best For Skin Types

All, Dry, Sensitive

Addresses

Dryness, Sensitivity, Barrier repair

Usage Frequency

Daily

Paeonia Lactiflora Root Extract products at Skintique

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What Is Paeonia Lactiflora Root Extract?

Paeonia lactiflora root extract is derived from the roots of the common peony plant, which has been used in traditional medicine for centuries. The extract contains multiple bioactive compounds, including paeoniflorin and galloyl-glucose derivatives, which contribute to its skin conditioning properties.

In skincare formulations, this ingredient functions as a skin conditioner, meaning it helps to maintain skin hydration and support the skin's natural barrier function. It appears in roughly 0.4% of skincare products, typically at modest concentrations.

How It Works

Paeonia lactiflora root extract works through multiple mechanisms. One of its key constituents, paeoniflorin, appears to modulate melanin synthesis by influencing tyrosinase activity and related signalling pathways in melanocytes. Another active compound, penta-O-galloyl-β-D-glucose, has been shown to enhance expression of genes involved in keratinocyte differentiation and skin barrier integrity.

The extract's overall conditioning effect likely results from its complex composition—containing over 50 identified constituents—which work together to support skin hydration and defensive function.

Clinical Evidence & References

In vitro studies suggest that Paeonia lactiflora root extract and its bioactive components have antioxidant and anti-inflammatory properties. Research in cell models indicates that paeoniflorin may influence melanin production, whilst other extract constituents appear to upregulate genes associated with skin barrier function and keratinocyte differentiation.

However, clinical evidence in human skin is limited. Most available research has been conducted in cell culture systems rather than on living skin, so the magnitude of these effects in real-world skincare use remains unclear. Safety assessments using toxicological concern thresholds suggest the ingredient is well-tolerated at cosmetic concentrations, but larger human studies would strengthen confidence in its efficacy.

How to Use

Paeonia lactiflora root extract is typically used as one component within a broader skincare formula rather than as a standalone ingredient. It works well alongside other conditioning and barrier-support ingredients. No special application technique is required; use the product as directed by the formulation instructions.

Safety & Precautions

Paeonia lactiflora root extract is generally considered safe for cosmetic use. Safety assessments indicate no genotoxic concerns at typical exposure levels, and the ingredient has a long history of traditional use in skincare.

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