Skin Conditioning

Polyglyceryl-10 Isostearate

INCI: POLYGLYCERYL-10 ISOSTEARATE

Reviewed by Kate · Last updated 14 Aug 2026

Also known as: Polyglyceryl-10 Isostearate

A synthetic emollient that conditions and softens the skin barrier

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Barrier repair

Usage Frequency

Daily

What Is Polyglyceryl-10 Isostearate?

Polyglyceryl-10 Isostearate is a synthetic conditioning agent derived from glycerin and isostearic acid. It functions as an emollient — a substance that helps soften and smooth the skin by forming a protective layer on the surface.

This ingredient is used in skincare formulations to improve texture and tactile feel, particularly in creams, serums and other leave-on products where a refined finish is desired. It appears in roughly 0.1% of skincare formulations, making it relatively uncommon.

How It Works

Polyglyceryl-10 Isostearate works by depositing a light occlusive layer on the skin's surface. This layer mimics the skin's natural lipid barrier, helping to lock in moisture and prevent water loss without leaving a heavy or sticky residue.

Because it is derived from multiple glycerol molecules linked to a fatty acid, it has both water-attracting and oil-attracting properties, allowing it to integrate smoothly into diverse formulation types.

Clinical Evidence & References

Published clinical data specifically on Polyglyceryl-10 Isostearate alone is limited. The ingredient's safety profile is established through its use in cosmetic formulations and compliance with regulatory standards, but robust efficacy studies are sparse in peer-reviewed literature.

Its conditioning and emollient properties are understood through general knowledge of similar glyceryl esters and polyols, which have a long history of safe use in skincare. Individual tolerance may vary depending on formulation context and skin sensitivity.

How to Use

Polyglyceryl-10 Isostearate is a passive conditioning agent, so no special application technique is required. Use products containing this ingredient as directed on the label, typically as part of your regular moisturising routine. It works well in layered routines and is compatible with most other skincare actives.

Safety & Precautions

Polyglyceryl-10 Isostearate is generally well-tolerated and has a low irritancy profile. Some individuals sensitive to fungal acne (Malassezia) may wish to avoid it, as fatty acid esters can potentially feed fungal growth in susceptible skin.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations