Polyglyceryl-3 Diisostearate
Reviewed by Rosie · Last updated 18 Aug 2026
Also known as: Isostearic Acid, Stearic Acid
Blend of isostearic acid and glycerin derivative | Primarily used as an emulsifier
Addresses
EWG Safety Score
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What Is Polyglyceryl-3 Diisostearate?
Polyglyceryl-3 diisostearate is primarily used as an emulsifier in cosmetics. Its lightweight feel and soft emolliency make it a desirable option to pair with or use in place of heavier emulsifiers. This ingredient also has cleansing properties but isn’t typically used for that purpose. It may be synthetic or plant-derived (the type uses) or, to a lesser extent, animal-derived.
Polyglyceryl-3 diisostearate is considered a diester (a chemical formed by reacting an acid with two alcohols) of the fatty acid isostearic acid and humectant polyglycerin-3.
Use levels of polyglyceryl-3 diisostearate in cosmetics range from 2–5%, depending on formulary needs. It’s insoluble in water but mixes readily with oils.
Clinical Evidence & References
Published Research
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Colloids and Surfaces, June 2017, pages 279–286 [https://www.sciencedirect.com/science/article/abs/pii/S0927775717302340]
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International Journal of Toxicology, August 2023, pages 5S–101S [https://journals.sagepub.com/doi/10.1177/10915818231174440]
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Scientific Reports, March 2023, pages 1–14 [https://www.nature.com/articles/s41598-023-31379-0]
From the Clinic
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Polyglyceryl-3 Dicitrate/Stearate
A synthetic emulsifier that stabilises oil and water in formulations
Polyglyceryl-3 Distearate
A synthetic emulsifier that stabilises oil-and-water formulations in skincare creams
Polyglyceryl-3 Laurate
A gentle emulsifier that helps bind water and oil in formulations
Polyglyceryl-3 Oleate
An emulsifying agent that helps blend oil and water in skincare formulations
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