Skin Conditioning

Polyquaternium-64

INCI: POLYQUATERNIUM-64

Reviewed by Daisy · Last updated 14 Aug 2026

A conditioning polymer that helps improve hair texture and manageability

What Is Polyquaternium-64?

Polyquaternium-64 is a positively charged conditioning polymer derived from cellulose, a natural plant-based material. It belongs to a class of ingredients known as quaternary ammonium compounds, which are widely used in hair and personal care products for their conditioning properties.

This ingredient works primarily as a hair conditioning agent, depositing onto the hair shaft to improve texture, reduce frizz, and enhance overall manageability. It is not typically used in facial skincare products but rather in shampoos, conditioners, and other hair care formulations.

How It Works

Polyquaternium-64 has a positive electrical charge that allows it to bind to hair fibres, which carry a negative charge. This electrostatic attraction helps the polymer adhere to the hair surface, forming a conditioning film that smooths the cuticle layer and reduces friction between strands.

This coating effect improves hair slip, reduces tangling, and can enhance shine and softness. The ingredient is particularly useful in rinse-off products like conditioners, where it can be easily removed during the next wash cycle.

Clinical Evidence & References

Polyquaternium-64 is a well-established ingredient in hair care with a long history of safe use in cosmetic formulations. Its conditioning efficacy is supported by its widespread use across the industry, though published clinical research specifically evaluating this polymer is limited in the peer-reviewed literature.

The ingredient's mechanism of action is well understood from a chemical perspective, and it has been approved for use in cosmetics in major regulatory regions including the EU and North America. Safety data from decades of consumer use supports its tolerability in rinse-off applications.

How to Use

Polyquaternium-64 is typically found in conditioners and other rinse-off hair products rather than leave-on formulations. Apply according to product instructions, usually after shampooing. For best results, allow the product to sit on damp hair for a minute or two before rinsing thoroughly. If using in a leave-on product, ensure it is applied to mid-lengths and ends rather than the scalp, as conditioning polymers can feel heavy on the roots.

Safety & Precautions

Polyquaternium-64 is generally well-tolerated and has a good safety profile when used as intended in rinse-off hair care products. It is not typically associated with irritation or adverse reactions in the general population.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations