Progesterone

Progesterone is a steroid hormone naturally produced in the body, primarily by the ovaries and adrenal glands. In skincare formulations, it is typically derived synthetically or from plant sources and formulated for topical application.As oestrogen levels decline during menopause, progesterone levels also shift significantly. This hormonal change affects skin structure, hydration and elasticity. Topical progesterone is used in skincare to address these menopausal skin changes, though its exact mechanism in cosmetic formulations remains an area of ongoing research.

Progesterone is thought to work by binding to progesterone receptors in skin cells, influencing collagen production and skin hydration. During menopause, declining progesterone levels contribute to reduced skin thickness and elasticity; topical application may help compensate for these hormonal changes.However, the depth of penetration of topical progesterone and the extent to which it reaches viable skin layers remains incompletely understood. Research on its cosmetic efficacy is still limited compared to other anti-aging ingredients.

Progesterone-containing products are typically applied as serums or creams once or twice daily to clean skin. For best results, consistency is important; allow at least 4-8 weeks of regular use before assessing visible changes. Combine with sun protection and other proven anti-aging ingredients such as retinoids or vitamin C for comprehensive support.

Topical progesterone has shown good tolerability in available studies with minimal adverse effects reported. Those with hormone-sensitive conditions should consult a healthcare provider before use.