Skin Conditioning

Pyridoxine

INCI: PYRIDOXINE

Reviewed by Kate · Last updated 14 Aug 2026

A B vitamin that supports skin and hair health through cellular function

Best For Skin Types

All

Addresses

Dryness, Barrier repair

Usage Frequency

Daily

What Is Pyridoxine?

Pyridoxine, also known as vitamin B6, is a water-soluble B vitamin that plays a role in amino acid metabolism and protein synthesis. In skincare formulations, it functions as a skin and hair conditioning agent, helping to maintain the structural integrity of the skin barrier and scalp health.

The ingredient is derived from natural sources or synthesised in laboratories. It is incorporated into skincare products at relatively modest concentrations to support the skin's natural maintenance processes.

How It Works

Pyridoxine is a coenzyme involved in numerous metabolic pathways, including the synthesis of neurotransmitters and amino acid metabolism. When applied topically or ingested, it supports the skin's natural processes of repair and maintenance by facilitating protein synthesis, which is essential for the production of structural proteins like collagen and keratin.

In the context of topical skincare, pyridoxine functions primarily as a skin conditioning agent, meaning it helps improve the skin's texture and hydration status rather than acting as an active treatment ingredient.

Clinical Evidence & References

Research indicates that pyridoxine deficiency can manifest as cutaneous abnormalities, including changes to skin texture, hair quality, and overall skin health. This suggests that adequate pyridoxine status is important for normal skin and hair function.

There is also emerging evidence that pyridoxine supplementation may help mitigate certain skin toxicities associated with systemic cancer treatments, though this research is still developing and consensus on optimal dosing and application has not yet been established. The evidence for topical pyridoxine in cosmetic formulations remains limited.

How to Use

Pyridoxine is typically used as part of a broader skincare routine rather than as a standalone treatment. Because it is most effective when part of the body's systemic nutrition, ensuring adequate dietary intake of B vitamins is equally important. It is well-tolerated in topical formulations and can be used daily as part of your regular skincare regimen.

Safety & Precautions

Pyridoxine is generally well-tolerated in topical skincare formulations and at dietary levels. No significant adverse effects have been reported for topical use at cosmetic concentrations.

Frequently Asked Questions

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