Quaternium-15
INCI: QUATERNIUM-15
Reviewed by Rosie · Last updated 14 Aug 2026
A synthetic preservative that prevents microbial growth in skincare formulations
Best For Skin Types
All
Addresses
Effective Concentrations
Up to 0.2%
Usage Frequency
As formulated in product
What Is Quaternium-15?
Quaternium-15 is a synthetic antimicrobial agent used primarily as a preservative in cosmetics and skincare products. It works by disrupting microbial cell membranes, preventing the growth of bacteria, fungi, and other microorganisms that could otherwise compromise product safety and stability.
As a preservative, its role is functional rather than therapeutic—it protects the product itself from contamination during manufacture and use, ensuring the formula remains safe and effective throughout its shelf life.
How It Works
Quaternium-15 is a cationic (positively charged) antimicrobial compound. It works by interacting with the negatively charged membranes of bacteria and fungi, disrupting their cell structure and preventing reproduction. This preservative action occurs at the product level rather than delivering direct benefits to the skin itself.
Clinical Evidence & References
Safety assessments by cosmetic regulatory bodies have established that Quaternium-15 is safe at concentrations up to 0.2% in finished products. At this level, research suggests it does not act as a skin sensitizer in most individuals. Animal studies have shown minimal systemic toxicity at cosmetically relevant exposures.
However, some individuals—particularly those with sensitive skin conditions—may experience contact sensitisation to this ingredient. Reports of sensitisation have been more common in North America than Europe. If you have a history of contact dermatitis or sensitive skin, patch testing before use is advisable.
How to Use
Quaternium-15 is a preservative, so you will encounter it as part of formulated products rather than using it as a standalone ingredient. Check product ingredient lists if you are avoiding this preservative; it will appear in the INCI declaration. If you have sensitive skin, introduce products containing it gradually and monitor your skin's response.
Safety & Precautions
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Potassium Paraben
A preservative that keeps formulations stable and free from microbial contamination
Propionic Acid
A naturally occurring preservative with emerging evidence for supporting skin barrier health
Propyl Benzoate
A preservative and fragrance ingredient with a long history of cosmetic use
Salvia Triloba Leaf Extract
A botanical extract with purifying and astringent properties, traditionally used in skincare formulations
Scutellaria Baicalensis Extract
A plant extract with purifying and antioxidant properties, studied for oil control and skin protection
Silver Chloride
A mineral preservative that helps maintain product stability and shelf life
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.