Quaternium-22
INCI: QUATERNIUM-22
Reviewed by Emma · Last updated 14 Aug 2026
A conditioning agent that helps improve texture and smoothness in haircare formulations
Usage Frequency
Daily
What Is Quaternium-22?
Quaternium-22 is a quaternary ammonium salt — a type of cationic (positively charged) conditioning agent commonly used in haircare products. It belongs to a broader class of compounds designed to improve the feel and manageability of hair fibres.
In formulations, Quaternium-22 works by depositing onto the hair surface, where its positive charge interacts with the negatively charged hair shaft. This interaction helps reduce friction between fibres, improving smoothness and reducing frizz.
How It Works
Quaternium-22 is a positively charged molecule that adheres to negatively charged hair fibres. This electrostatic attraction forms a thin conditioning film on the hair surface.
This film reduces friction between individual hair strands and helps seal the hair cuticle, resulting in improved combability, reduced breakage during styling, and a smoother overall appearance.
Clinical Evidence & References
Quaternium-22 is well-established in the haircare industry and has a long history of safe use. However, specific peer-reviewed clinical studies evaluating this ingredient in isolation are limited in available literature.
Its efficacy is supported by widespread industry adoption and consumer tolerance data, though more targeted research would help clarify its performance compared to alternative conditioning agents in different formulation contexts.
How to Use
Quaternium-22 is typically found in rinse-off haircare products such as conditioners and treatment masks, where it can deposit effectively onto the hair. For best results, apply to mid-lengths and ends of damp hair, leave for the recommended time, and rinse thoroughly. It works well in combination with other conditioning agents.
Safety & Precautions
Frequently Asked Questions
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