S-Palmitoylglutathione

S-Palmitoylglutathione is a modified version of glutathione, a naturally occurring antioxidant compound found in cells throughout the body. The addition of a palmitoyl chain (a type of fatty acid) to glutathione makes it more stable and better able to penetrate the skin barrier compared to standard glutathione, which tends to break down quickly.In skincare formulations, it functions as an antioxidant—meaning it helps neutralise free radicals, unstable molecules that can damage skin cells and contribute to visible signs of ageing and inflammation.

Free radicals are produced naturally in skin through sun exposure, pollution, and normal cellular processes. These unstable molecules can damage proteins and lipids in skin cells, accelerating visible signs of ageing and contributing to inflammation. S-Palmitoylglutathione works by donating electrons to free radicals, stabilising them and preventing this damage.The palmitoyl modification improves the ingredient's ability to remain stable in formulations and penetrate the outer layers of skin, where environmental damage typically occurs first.

S-Palmitoylglutathione is typically found in serums, moisturisers, and targeted treatments. It works well alongside other antioxidants like vitamin C or niacinamide. For best results, use consistently as part of your regular routine. Store products containing this ingredient away from direct sunlight and heat, as antioxidants can degrade when exposed to light.

S-Palmitoylglutathione is generally well-tolerated by most skin types with minimal reported irritation. As with any new ingredient, patch test first if you have sensitive skin.