Spermidine

Spermidine is a small organic molecule known as a polyamine, found naturally in cells throughout the body and in certain foods including wheat germ, soy, and aged cheese. In skincare, it functions as an antioxidant and conditioning agent, helping to protect skin from oxidative stress and maintain hydration.The ingredient works by interacting with cellular processes that influence skin health, particularly those related to cellular renewal and protection against environmental damage.

Spermidine protects skin by neutralising free radicals—unstable molecules generated by UV exposure, pollution, and natural metabolism that damage skin cells and accelerate ageing. As an antioxidant, it donates electrons to these free radicals, rendering them harmless.Additionally, spermidine may support autophagy, a cellular housekeeping process where the body removes damaged components and regenerates healthy ones. This cellular maintenance is thought to contribute to skin resilience and a more youthful appearance over time.

Spermidine is typically found in serums, creams, and treatments at low concentrations. It works well alongside other antioxidants and can be used daily as part of a standard skincare routine. There is no specific timing requirement, though applying it to clean skin before moisturiser may optimise absorption. No special protocols are needed.

Spermidine is generally well-tolerated in skincare formulations. No significant adverse effects or contraindications have been widely reported, though patch testing is advisable for those with very sensitive skin or known sensitivities to polyamines.