Spirodela Polyrhiza Extract
INCI: SPIRODELA POLYRHIZA EXTRACT
Reviewed by Daisy · Last updated 2 Jun 2026
A plant extract with traditional use in treating inflammatory skin conditions
Best For Skin Types
All, Sensitive
Addresses
Usage Frequency
Daily
What Is Spirodela Polyrhiza Extract?
Spirodela polyrhiza extract comes from a small aquatic plant (duckweed) that has been used in traditional Chinese, Japanese and Korean medicine for centuries to address skin complaints including eczema, rashes and itching. The extract is obtained through solvent extraction, typically using ethanol, to concentrate the plant's active compounds.
In skincare formulations, this ingredient functions as a skin conditioner, working to support the skin's natural balance and resilience. The plant contains multiple bioactive compounds including flavonoids and phenolic acids that appear to interact with skin cells and inflammatory pathways.
How It Works
The extract appears to work through multiple mechanisms. Research indicates it can modulate specific ion channels (Orai1 and TRPV3) involved in atopic dermatitis, potentially reducing the activation signals that trigger inflammation and itching. It may also inhibit the release of inflammatory mediators from mast cells, specialised immune cells that contribute to allergic skin reactions.
Additionally, the extract seems to influence key inflammatory pathways (MAPK signalling) that regulate the skin's immune response, whilst supporting barrier function through modulation of immune balance.
Clinical Evidence & References
In-vitro and animal studies show promise. Research using mouse models of contact dermatitis and atopic dermatitis demonstrated that spirodela extract reduced skin lesions, inflammatory markers (TNF and IL-6), and itching-related ion channel activity. One study found that combining spirodela extract with olive leaf extract produced additive benefits for atopic dermatitis symptoms.
However, human clinical data remains limited. Most evidence comes from preclinical studies and animal models rather than controlled human trials, so efficacy in real-world skincare use is not yet established. Further research in human subjects would strengthen confidence in these findings.
Published Research
How to Use
This ingredient is typically incorporated into serums, creams and treatment products at low to moderate concentrations. It can generally be used daily as part of routine skincare, though those with sensitive or reactive skin may wish to introduce it gradually to monitor tolerance. It appears compatible with other skincare actives, though patch testing is always prudent when layering multiple treatments.
Safety & Precautions
Frequently Asked Questions
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