Best For Skin Types
All skin types
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Acetyl Dipeptide-1 Cetyl Ester?
Acetyl dipeptide-1 cetyl ester is a lab-engineered synthetic peptide that combines acetic acid and cetyl alcohol with dipeptide-1, a peptide composed of amino acids arginine and tyrosine. Dipeptide-1 is found naturally in the body and plays a role in maintaining skin’s elasticity.
Research has shown that topical application of this peptide protects collagen-making cells known as fibroblasts from the visible impact of glycation, a process in which destructive sugar molecules progressively weaken skin’s supportive elements.
This ingredient has also been shown to thwart irritation on skin’s surface that would otherwise result in stinging or burning sensations. As such, it’s a very good option to pair with bio-active ingredients that can be more sensitizing for some people.
Recommended usage levels of this peptide range from 3–4%; however, since the peptide portion itself is part of a blend, the actual amount of peptide needed to gain benefit is much lower, in the parts per million level. It is considered safe as used in cosmetics.
Benefits for Your Skin
Clinical Evidence & References
Published Research
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Acetyl Dipeptide-1 Cetyl Ester: Anti-irritation peptide Molecules, 2019
Frequently Asked Questions
From the Clinic
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3-Ascorbyl Carbonyl Dipeptide-17
A peptide derivative that supports skin conditioning and texture refinement
Acetyl Cyclohexapeptide-34
A peptide that supports skin's natural conditioning and structural function
Acetyl Decapeptide-3
A peptide that supports skin conditioning and cellular resilience
Acetyl Dipeptide-3 Aminohexanoate
A peptide derivative that supports skin conditioning and hydration
Acetyl Dipeptide-31 Amide
A small peptide designed to address inflammation and visible signs of ageing
Acetyl Dipeptide-32 Amide
A small peptide designed to support skin's natural resilience and reduce visible signs of ageing
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