Acetyl Dipeptide-31 Amide

Acetyl Dipeptide-31 Amide (commonly abbreviated as AP31) is a synthetic peptide—a short chain of amino acids—developed specifically for skincare. Its small molecular size allows it to penetrate the skin relatively effectively, distinguishing it from larger peptide molecules that may sit on the surface.In formulations, this ingredient functions as a skin conditioning agent. Research suggests it works by modulating the skin's inflammatory response and supporting the appearance of firmness and elasticity.

Acetyl Dipeptide-31 Amide appears to work by suppressing the release of inflammatory signalling molecules (cytokines) within the skin. In laboratory studies, it reduced levels of interleukin-4, interleukin-6, interleukin-8, interleukin-17, and tumour necrosis factor alpha—all markers associated with skin inflammation and accelerated ageing.By reducing this inflammatory activity, the ingredient may help preserve skin structure and appearance, particularly in relation to fine lines, loss of firmness, and uneven tone.

This ingredient is typically incorporated into serums, moisturisers, and targeted treatments. Use it as directed within your chosen product—usually daily as part of your morning or evening routine. It pairs well with other antioxidants and hydrating ingredients. For best results, consistency over time is more important than concentration.

Acetyl Dipeptide-31 Amide appears to be well-tolerated across different skin types with no significant adverse effects reported in available clinical studies. As with any active ingredient, patch testing is advisable if you have particularly sensitive skin.