Acetyl Hexapeptide-37
INCI: Peptides
Reviewed by Kate · Last updated 5 Aug 2026
Also known as: Peptides, Amino Acids
Synthetic peptide Composed of amino acids (alanine, proline, serine, and glycine)
Best For Skin Types
All skin types
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Acetyl Hexapeptide-37?
Acetyl hexapeptide-37 is a synthetic peptide composed of the amino acids alanine, proline, serine and glycine. This peptide works with the water channels (known as aquaporins) in skin's surface layers, helping to provide adequate, balanced hydration between skin's layers, a process which alleviates signs of dry, dehydrated skin.
Although there isn’t independent research confirming the effectiveness of this peptide on skin, the supplier (Lipotec) has made the results of their research available in a lengthy technical report that’s supported by third-party studies. Between this information and the wider field of published scientific research on peptides for skin, we feel confident recommending acetyl hexapeptide-37, particularly for dehydrated skin.
Frequently Asked Questions
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