Dipalmitoyl Hydroxyproline
Shop Dipalmitoyl Hydroxyproline skincare at Skintique →
INCI: Proline
Reviewed by Rosie · Last updated 14 Aug 2026
Also known as: Proline, Palmitic Acid, Peptides
An oil-soluble derivative of hydroxyproline Hydroxyproline is the primary amino acid in skin’s collagen
At a glance
EWG Safety Score
What Is Dipalmitoyl Hydroxyproline?
Dipalmitoyl hydroxyproline is an oil-soluble version of hydroxyproline, which is the primary amino acid in collagen. Making it oil-soluble improves penetration into skin and lips, where it works to signal skin from the uppermost layers to repair its supportive elements, leading to fewer visible lines and wrinkles. In essence, hydroxyproline is considered a signal peptide.
This ingredient works best when paired with oils or glycols since both increase its affinity for skin. Along with supporting skin’s collagen, it also offsets collagen-degrading enzymes known as matrix metalloproteinases. When these enzymes proliferate unchecked, collagen is weakened, leading to signs of sagging and thinning lips.
The recommended usage level of dipalmitoyl hydroxyproline is 0.1-2%; clinical studies from suppliers have shown measurable improvement of wrinkle depth when used at 0.5%.
Palmitic acid is considered safe for skin, as are proline and hydroxyproline since the latter two are found naturally in skin and its collagen.
Clinical Evidence & References
How widely it's used
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- DIPALMITOYL HYDROXYPROLINE
- EC Number
- 255-490-0
- Function
- Antistatic, Hair Conditioning, Skin Conditioning
Frequently Asked Questions
From the Clinic
Not sure what your skin actually needs?
Two minutes, a few questions, and we’ll point you at what matters — no guesswork.
Take the skin quizRelated Ingredients
Diaminopropionoyl Tripeptide-33
A peptide designed to support skin's structural integrity and conditioning
Dicetyl Dipeptide-9
A peptide derivative designed to support skin structure and delivery systems in formulations
Dimer D-Phenylalanyl Tripeptide-75
A peptide derivative that supports skin conditioning and structural integrity
Dipalmitoylethyl Dimonium Chloride
A quaternary ammonium compound primarily used in hair and scalp formulations
Dipeptide Diaminobutyroyl Benzylamide Diacetate
A peptide compound studied for its potential to support skin firmness and reduce visible wrinkles
Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-133
A peptide ingredient designed to support skin firmness and reduce the appearance of expression lines
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.