Peptides

Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-133

INCI: DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE OLIGOPEPTIDE-133

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-133

A peptide ingredient designed to support skin firmness and reduce the appearance of expression lines

Best For Skin Types

All, Mature

Addresses

Fine lines, Firmness, Elasticity

Usage Frequency

Daily

What Is Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-133?

Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-133 is a synthetic peptide — a short chain of amino acids — developed for skincare formulations. Peptides are thought to communicate with skin cells and may help support the production of structural proteins like collagen.

This ingredient functions as a skin conditioning agent and is typically included in serums and treatments targeting signs of ageing, particularly dynamic wrinkles caused by facial expressions.

How It Works

This peptide is believed to work by signalling skin cells to maintain and support the structural proteins responsible for firmness and elasticity. By helping to preserve collagen and elastin fibres, it may reduce the depth and visibility of expression lines over time.

It is typically formulated alongside other peptides and supporting ingredients to create a synergistic anti-ageing effect, rather than working in isolation.

Clinical Evidence & References

A clinical study involving 92 participants examined a serum containing this peptide alongside acetyl hexapeptide-8, gluconolactone, niacinamide and laminaria extract. The combination showed measurable improvements in static wrinkles, dynamic wrinkles, skin texture and biomarkers associated with skin ageing, including collagen and elastic fibre content.

However, because this ingredient is typically used in multi-active formulations rather than alone, it is difficult to isolate its individual contribution. More research specifically evaluating this peptide in isolation would help clarify its standalone efficacy.

How to Use

Apply to clean skin as part of a serum or treatment, typically in the morning and evening. Allow the product to dry before layering other skincare steps. Results from peptide-based products tend to develop gradually over weeks to months of consistent use, so patience is important. Combine with broad-spectrum SPF during the day, as peptides work best when skin barrier health is optimised.

Safety & Precautions

This ingredient is generally well-tolerated in skincare formulations. Those with very sensitive skin should patch test first, though peptides are typically considered low-irritancy.

Frequently Asked Questions

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