Best For Skin Types
All, Sensitive
Addresses
Usage Frequency
Daily
What Is Dipeptide-1?
Dipeptide-1 is a short-chain peptide—a molecule made of two amino acids linked together. Peptides are fragments of proteins that are small enough to be absorbed by the skin, making them useful in topical skincare formulations.
In cosmetic products, dipeptide-1 functions primarily as a skin and hair conditioning agent. It is often used in formulations designed to address sensitive or reactive skin, where its potential calming properties may help reduce discomfort and support skin comfort.
How It Works
Dipeptide-1 appears to work by interacting with sensory receptors in the skin that trigger sensitivity responses. When applied topically, it may help dampen these signals, reducing the burning or stinging sensations associated with sensitive skin.
As a conditioning agent, it also helps to coat and hydrate the skin surface, which can contribute to a smoother texture and improved skin feel.
Clinical Evidence & References
A controlled study comparing dipeptide-1 (in the form of acetyl dipeptide-1 cetyl ester) with another calming ingredient found it reduced capsaicin-induced stinging in volunteers with sensitive skin. This suggests a measurable benefit for those experiencing sensitivity reactions.
Dipeptide-1 has also been investigated as a component in advanced delivery systems designed to enhance topical efficacy. However, evidence remains relatively limited, and more research would help clarify its broader skincare applications and optimal concentrations.
Published Research
How to Use
Dipeptide-1 is typically found in leave-on products such as serums, moisturisers, and toners formulated for sensitive skin. Apply it as part of your regular routine, allowing each layer to absorb before applying the next product. It works well in combination with other calming and barrier-supporting ingredients.
Safety & Precautions
Frequently Asked Questions
From the Clinic
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Take the skin quizRelated Ingredients
Dipalmitoylethyl Dimonium Chloride
A quaternary ammonium compound primarily used in hair and scalp formulations
Dipeptide Diaminobutyroyl Benzylamide Diacetate
A peptide compound studied for its potential to support skin firmness and reduce visible wrinkles
Dipeptide Diaminobutyroyl Benzylamide Diacetate Oligopeptide-133
A peptide ingredient designed to support skin firmness and reduce the appearance of expression lines
Dipeptide-12
A peptide that may support skin renewal and reduce visible signs of ageing
Dipeptide-15
A peptide that supports skin and hair conditioning through protein-derived molecules
Dipeptide-2
A synthetic peptide made by combining tryptophan and valine. May be helpful for alleviating undereye puffiness.
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