Peptides

Dipeptide-2

INCI: Peptides

Reviewed by Kate · Last updated 18 Aug 2026

Also known as: Peptides, Amino Acids

A synthetic peptide made by combining tryptophan and valine. May be helpful for alleviating undereye puffiness.

What Is Dipeptide-2?

Dipeptide-2 is a small, less complex synthetic peptide made up of the amino acids tryptophan and valine.\n\nStudies from one ingredient supplier indicate that this peptide as part of a blend may reduce the look of puffy eyes; however, to date independent research hasn’t supported this claim.\n\nGenerally, dipeptide-2 is considered a skin conditioning ingredient whose smaller size allows it to easily penetrate skin’s uppermost layers where it can assist with skin renewal and replenishment. For now, that’s the most compelling reason to consider skin care products that contain it.\n\nRecommended usage levels on this peptide by itself aren’t available; however, usage levels when this peptide is part of a blend range from 0.5–5%, depending on desired results.

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