Dipeptide-4
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Reviewed by Kate · Last updated 18 Aug 2026
Also known as: Anti-Puffiness Peptide, Drainage Peptide
Anti-oedema peptide for reducing puffiness
At a glance
Addresses
EWG Safety Score
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What Is Dipeptide-4?
Dipeptide-4 is a synthetic peptide composed of two amino acids designed to address fluid retention in the skin. It works by improving lymphatic circulation and reducing the accumulation of excess fluid in tissues.
This peptide is particularly effective in eye care formulations where puffiness and under-eye bags are concerns. By enhancing microcirculation and supporting lymphatic drainage, it helps create a more refreshed, awake appearance.
Dipeptide-4 is often combined with caffeine and other decongestant ingredients for enhanced results in targeted treatments for the delicate eye area.
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- DIPEPTIDE-4
- EC Number
- -
- Function
- Skin Conditioning
From the Clinic
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Dipeptide-12
A peptide that may support skin renewal and reduce visible signs of ageing
Dipeptide-15
A peptide that supports skin and hair conditioning through protein-derived molecules
Dipeptide-2
A synthetic peptide made by combining tryptophan and valine. May be helpful for alleviating undereye puffiness.
Dipeptide-5
A peptide fragment that supports skin conditioning and structural integrity
Dipeptide-8
A peptide that supports skin conditioning and structural integrity
Dual MiniProteins
Cutting-edge peptide complex for targeted skin firming
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