Peptides

Dipeptide-4

Reviewed by Kate · Last updated 18 Aug 2026

Also known as: Anti-Puffiness Peptide, Drainage Peptide

Anti-oedema peptide for reducing puffiness

Addresses

puffiness, dark circles, tired eyes, fluid retention

What Is Dipeptide-4?

Dipeptide-4 is a synthetic peptide composed of two amino acids designed to address fluid retention in the skin. It works by improving lymphatic circulation and reducing the accumulation of excess fluid in tissues.

This peptide is particularly effective in eye care formulations where puffiness and under-eye bags are concerns. By enhancing microcirculation and supporting lymphatic drainage, it helps create a more refreshed, awake appearance.

Dipeptide-4 is often combined with caffeine and other decongestant ingredients for enhanced results in targeted treatments for the delicate eye area.

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