Dipeptide-12

Dipeptide-12 is a synthetic peptide — a short chain of amino acids — designed to support the skin's natural renewal processes. Peptides work by signalling to skin cells, encouraging them to function optimally and maintain their structural integrity.This ingredient functions primarily as a skin conditioner, helping to maintain hydration and support the skin barrier. Some formulations of dipeptide-12 have been modified with additional molecules to enhance its activity, which may influence its performance in skincare products.

Dipeptide-12 is believed to work by activating cellular processes involved in renewal and waste removal — particularly autophagy, which is the skin's natural 'cleaning' mechanism. When this process functions well, cells can better maintain their health and appearance.The ingredient may also influence pathways related to cell longevity and stress response, which are relevant to how skin ages. However, the exact mechanisms in living skin remain an area of ongoing research.

Dipeptide-12 is typically used in moisturisers and serums applied once or twice daily to clean skin. For best results, apply to damp skin to support hydration, and layer with other compatible actives as needed. Results from clinical trials generally appeared over 4 weeks of consistent use.

Dipeptide-12 is generally well-tolerated with minimal adverse effects reported in available studies. As with any skincare ingredient, those with sensitive skin should perform a patch test first.