Peptides

Dimer D-Phenylalanyl Tripeptide-75

INCI: DIMER D-PHENYLALANYL TRIPEPTIDE-75

Reviewed by Emma · Last updated 2 Jun 2026

Also known as: Dimer D-phenylalanyl Tripeptide-75

A peptide derivative that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Sensitive, Mature

Addresses

Dryness, Barrier repair, Sensitivity

Usage Frequency

Daily

What Is Dimer D-Phenylalanyl Tripeptide-75?

Dimer D-Phenylalanyl Tripeptide-75 is a synthetic peptide—a short chain of amino acids—designed to function as a skin conditioning agent. Peptides are commonly used in skincare because they can interact with skin cells to support various aspects of skin health and appearance.

This particular peptide is formulated to help maintain skin's moisture balance and support the skin barrier. It works at the cellular level, where its structure allows it to communicate with skin cells in ways that may improve hydration and skin texture over time.

How It Works

Peptides communicate with skin cells through cell-surface receptors, essentially sending signals that encourage beneficial cellular behaviour. In this case, Dimer D-Phenylalanyl Tripeptide-75 is thought to signal cells to optimise their moisture management and support structural proteins that keep skin firm and hydrated.

The dimer structure (two linked units) may enhance penetration or stability compared to single peptide chains, potentially allowing the ingredient to work more effectively within the skin.

Clinical Evidence & References

Published clinical data specifically on this ingredient is limited, which is common for newer or more specialised peptides. Most evidence supporting peptide efficacy in skincare comes from broader peptide research, which shows promise for skin conditioning and barrier support.

The ingredient is used in cosmetic formulations based on theoretical benefits and preliminary findings, but consumers should understand that individual results may vary and long-term efficacy studies are not widely available.

How to Use

This ingredient is typically found in serums, moisturisers, and hydrating products. It works well alongside other hydrating or barrier-supporting ingredients such as hyaluronic acid or ceramides. Apply to clean skin and layer with your other skincare products as directed on the product label. Consistent use over several weeks is generally recommended to assess any benefits.

Safety & Precautions

Dimer D-Phenylalanyl Tripeptide-75 is generally well-tolerated and suitable for most skin types, including sensitive skin. No significant adverse effects have been reported in cosmetic use.

Frequently Asked Questions

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