Peptides

Acetyl Tetrapeptide-2

Reviewed by Kate · Last updated 18 Aug 2026

Synthetic peptide Support skin’s extracellular matrix

Best For Skin Types

All skin types

Usage Frequency

As directed on product packaging

What Is Acetyl Tetrapeptide-2?

Acetyl tetrapeptide-2 is a lab-synthesized peptide created by the acetylation of tetrapeptide-2. Acetylation is the process of adding an acetyl group (molecular compounds that modify proteins and enzymes) to a compound to change its function. Acetyl tetrapeptide-2 is derived from thymopoietin, a polypeptide originating in the thymus gland.

Research finds acetyl tetrapeptide-2 helps support skin’s extracellular matrix and helps improve skin’s elasticity. It does so by encouraging healthy levels of elastin (elastin being one of the chief substances responsible for skin’s youthful “bounce”). The peptide helps reinforce skin’s barrier, making it more resilient to environmental stressors and ageing.

Studies have also demonstrated that acetyl tetrapeptide-2 has skin soothing properties.

The supplier-recommended use level is 2–10% with the peptide being suspended in a water and dextran solution.

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