Adenosine
Reviewed by Rosie · Last updated 14 Aug 2026
Helps improve the visible appearance of wrinkles Has soothing properties
Best For Skin Types
All skin types
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Adenosine?
Adenosine is a water-soluble yeast-derived ingredient that functions as a good soothing and skin-restoring agent. It has proven anti-wrinkle benefits and is a safe, beneficial ingredient all skin types can use. Studies also indicate strong potential for soothing properties.
One of the particularly exceptional qualities of adenosine is that it’s a natural component of the body and its receptors have specifically been identified in skin cells, allowing for a direct connection and impressive effectiveness when applied topically.
In one study (conducted by L’Oreal) adenosine showed efficacy in as low as 0.1% concentration for improving deep wrinkles in the periorbital area (i.e. crow’s feet) as well as glabellar frown lines (known as the 11s between brows).
In 2020, the Expert Panel for Cosmetic Ingredient Safety concluded that adenosine was safe in concentrations of up to 1% in leave on skin care products.
Adenosine is described as a white, odorless, crystalline powder in its raw form.
Benefits for Your Skin
Clinical Evidence & References
- PubChem, Accessed May 2021, ePublication
- Cosmetic Ingredient Review, September 2020, pages 1-38
- Experimental Dermatology, August 2014, pages 553-554
- Journal of Investigative Dermatology, August 2011, pages 526-546
- International Journal of Cosmetic Science, December 2006, pages 447-451
- British Journal of Pharmacology, October 2008, issue 4, pages 475-486
- PloS One, May 2008 (ePublication)
- International Journal of Cosmetic Science, August 2006, pages 447-451
Published Research
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Adenosine and skin: roles in regeneration and repair Journal of Clinical Medicine, 2017
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Anti-wrinkle effect of adenosine in skin Journal of Dermatological Science, 2009
Frequently Asked Questions
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