Skin Conditioning

C10-40 Isoalkylamidopropylethyldimonium Ethosulfate

INCI: C10-40 ISOALKYLAMIDOPROPYLETHYLDIMONIUM ETHOSULFATE

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: C10-40 Isoalkylamidopropylethyldimonium Ethosulfate

A conditioning agent that helps reduce static and improve hair manageability in rinse-off formulas

Usage Frequency

Daily or as directed

What Is C10-40 Isoalkylamidopropylethyldimonium Ethosulfate?

C10-40 Isoalkylamidopropylethyldimonium Ethosulfate is a quaternary ammonium compound (quat) commonly used in hair and scalp care products. Despite its complex name, it functions as a conditioning agent designed to coat the hair fibre and reduce friction between strands.

This ingredient is classified as an antistatic agent, meaning it helps neutralise the electrical charge that builds up on hair and can cause frizz, tangles, and flyaways. It is typically found in rinse-off formulas rather than leave-on skincare.

How It Works

The ingredient works through electrostatic principles. Hair develops a negative charge when wet or dry, which causes strands to repel one another and create frizz. C10-40 Isoalkylamidopropylethyldimonium Ethosulfate carries a positive charge that neutralises this repulsion, allowing hair to lie flatter and feel smoother.

Additionally, the hydrophobic (water-repelling) portion of the molecule adheres to the hair cuticle, forming a conditioning film. This film reduces friction between strands, making hair easier to comb and style whilst improving perceived texture and shine.

Clinical Evidence & References

Published clinical data specific to this ingredient is limited. Most evidence for its efficacy comes from cosmetic chemistry literature and manufacturer testing rather than independent peer-reviewed studies.

Industry data suggests it performs adequately as a conditioning and antistatic agent in rinse-off formulations. Like other quats, it is generally recognised as safe in cosmetic use at approved concentrations, though some jurisdictions maintain restrictions on certain quaternary ammonium compounds.

How to Use

This ingredient is primarily found in shampoos and conditioners designed for frizz control and detangling. It is rinsed off immediately after application, so exposure time is brief. For best results, use as directed on the product label—typically applying conditioner to mid-lengths and ends of damp hair, leaving for a few moments, then rinsing thoroughly.

Safety & Precautions

Generally well-tolerated in rinse-off formulas at typical cosmetic concentrations. Some individuals with sensitive scalps may experience irritation; discontinue use if itching or redness occurs. It is not designed for leave-on contact with skin.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations