Skin Conditioning

Centella Asiatica Callus Culture Lysate

INCI: CENTELLA ASIATICA CALLUS CULTURE LYSATE

Reviewed by Rosie · Last updated 2 Jun 2026

Also known as: Centella Asiatica Callus Culture Lysate

A plant cell culture extract designed to support skin barrier function and calm irritation

Best For Skin Types

All, Sensitive, Combination

Addresses

Sensitivity, Redness, Barrier repair, Irritation

Usage Frequency

Daily

What Is Centella Asiatica Callus Culture Lysate?

Centella Asiatica Callus Culture Lysate is derived from plant cell cultures of Centella Asiatica (also known as Gotu Kola), a traditional botanical used in Asian skincare for centuries. Rather than extracting from whole leaves, this ingredient is produced by cultivating plant cells in a controlled laboratory environment, then processing them into a lysate—essentially a concentrated form of the plant's beneficial compounds.

As a skin conditioning agent, this ingredient is primarily used to support the skin's natural barrier function and help reduce visible signs of irritation and redness. It works by delivering plant-derived compounds that may help calm reactive skin.

How It Works

The lysate form of this ingredient contains bioactive compounds from Centella Asiatica plant cells. These compounds are thought to work by signalling to skin cells to strengthen structural proteins and lipids that make up the barrier, whilst also providing antioxidant and anti-inflammatory benefits that help calm reactive skin responses.

Because it's a cell culture extract rather than a whole plant extract, it offers a more standardised and concentrated delivery of these beneficial compounds, which may enhance its efficacy in formulations.

Clinical Evidence & References

Research on Centella Asiatica in general has established its traditional use for soothing irritated skin, and some studies suggest it can support barrier function and reduce visible redness. However, specific clinical evidence for the callus culture lysate form in particular is limited in peer-reviewed literature.

Most evidence for this ingredient comes from in vitro studies and manufacturer data rather than large-scale human trials. It is generally well-tolerated and considered a gentle addition to skincare formulations, though individual responses can vary.

How to Use

This ingredient is most commonly found in serums, essences, toners, and hydrating moisturisers. It can be used daily as part of your regular skincare routine. If your skin is reactive or severely compromised, introduce it gradually alongside other calming ingredients such as niacinamide or ceramides to support barrier repair.

Safety & Precautions

Generally well-tolerated and suitable for sensitive skin. Rare cases of contact sensitivity have been reported, so patch test if you have known sensitivity to plant extracts.

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