Antioxidant

Centella Asiatica Callus Culture

INCI: CENTELLA ASIATICA CALLUS CULTURE

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Centella Asiatica Callus Culture

Plant cell culture extract with antioxidant properties to support skin resilience

Best For Skin Types

All, Sensitive, Mature, Dry

Addresses

Fine lines, Oxidative stress, Dryness, Sensitivity

Usage Frequency

Daily

What Is Centella Asiatica Callus Culture?

Centella asiatica callus culture is a lab-grown plant cell extract derived from the centella asiatica plant, commonly known as cica or gotu kola. Rather than harvesting the whole plant, callus culture involves cultivating undifferentiated plant cells in controlled conditions, which allows for sustainable, large-scale production of the plant's beneficial compounds without depleting wild populations.

In skincare formulations, this ingredient functions as both an antioxidant and skin conditioner. It contains phytochemicals that help the skin defend against oxidative stress, a process implicated in visible ageing.

Benefits for Your Skin

How It Works

Oxidative stress occurs when free radicals accumulate in the skin, overwhelming the body's natural antioxidant defences. This process is thought to accelerate visible signs of ageing. Centella asiatica callus culture contains compounds that act as antioxidants, meaning they can neutralise free radicals and reduce oxidative burden on skin cells.

The extract also supports skin conditioning by helping to maintain moisture and suppleness, though the exact mechanisms warrant further investigation.

Clinical Evidence & References

Research suggests that centella asiatica extracts, including those from callus culture, possess antioxidant activity and may support skin's resilience against oxidative stress. Studies indicate the ingredient has potential as an anti-ageing agent, particularly because it may help dermal fibroblasts (the cells responsible for collagen production) maintain their function under oxidative stress.

A safety panel has confirmed that centella asiatica callus culture is safe in cosmetics at typical concentrations when formulated to be non-sensitising. However, most evidence comes from laboratory and preliminary studies; larger human trials would strengthen our understanding of its practical benefits in skincare.

How to Use

This ingredient is typically found in serums, moisturisers and targeted treatments. It works well alongside other antioxidants and can be used daily. Because centella asiatica extracts are generally well-tolerated, they suit most skincare routines, though as with any new ingredient, introduce it gradually if you have sensitive skin.

Safety & Precautions

Centella asiatica callus culture is considered safe in cosmetics at standard concentrations when formulated to be non-sensitising. Those with known sensitivity to centella asiatica should avoid it.

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