Preservative

Cetrimonium Bromide

INCI: CETRIMONIUM BROMIDE

Reviewed by Emma · Last updated 14 Aug 2026

Also known as: Cetrimonium Bromide

A preservative and purifying agent that helps maintain product stability and safety

Best For Skin Types

All

Addresses

Product safety, For Blemish-Prone Skin

Usage Frequency

Daily

What Is Cetrimonium Bromide?

Cetrimonium bromide (CTAB) is a quaternary ammonium compound—a type of positively charged molecule derived from ammonium salts. In skincare formulations, it functions primarily as a preservative and antimicrobial agent, helping to prevent microbial contamination and extend product shelf life.

It also has antistatic and emulsifying properties, making it useful in formulations where these functions are needed. Whilst commonly used in disinfectant products, it appears in a small proportion of skincare products at relatively low concentrations.

How It Works

Cetrimonium bromide works by disrupting the cell membranes of bacteria and fungi. Its positively charged molecular structure allows it to interact with and destabilise the negatively charged outer layers of microbial cells, inhibiting their growth and reproduction.

In formulations, it also reduces static electricity and can help stabilise mixtures of oils and water-based ingredients through its emulsifying properties, contributing to overall product performance.

Clinical Evidence & References

Cetrimonium bromide has a documented history of antimicrobial effectiveness in clinical and industrial settings. However, research into its specific dermal effects in skincare formulations remains limited.

Available evidence suggests that quaternary ammonium compounds like cetrimonium bromide may carry a risk of contact sensitivity or irritation, particularly at higher concentrations, over prolonged exposure, or on compromised skin barriers. The research base for this ingredient in cosmetic skincare specifically is smaller than for its use as a surface disinfectant, so individual tolerance can vary.

How to Use

Products containing this ingredient should be used as directed. If you have a known sensitivity to quaternary ammonium compounds or a history of contact dermatitis, introduce any new product slowly and monitor your skin's response. Discontinue use if irritation develops.

Safety & Precautions

Generally recognised as safe in cosmetic formulations at typical use levels. However, quaternary ammonium compounds can trigger contact sensitivity or irritation in some individuals, particularly those with sensitive or damaged skin barriers.

Frequently Asked Questions

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