Preservative

Chloroacetamide

INCI: CHLOROACETAMIDE

Reviewed by Daisy · Last updated 14 Aug 2026

A preservative that protects skincare formulations from microbial contamination

Best For Skin Types

All

Usage Frequency

Daily

What Is Chloroacetamide?

Chloroacetamide is a synthetic preservative used in cosmetic and skincare formulations to prevent the growth of bacteria, fungi and other microorganisms. Its primary role is to maintain product stability and safety throughout its shelf life, ensuring the formula remains effective and free from harmful contamination.

As a preservative, chloroacetamide works at low concentrations within finished products. It is not an active skincare ingredient designed to address specific skin concerns, but rather a functional component that enables other beneficial ingredients to remain potent and safe for use.

How It Works

Chloroacetamide functions as a preservative by inhibiting the growth of microorganisms including bacteria and fungi within cosmetic formulations. It achieves this through its action on microbial cell membranes, disrupting their normal function and preventing proliferation.

By maintaining microbiological control, chloroacetamide protects both the product and the consumer, ensuring that the formula delivered matches the formulation developed and tested for safety.

Clinical Evidence & References

Research suggests chloroacetamide derivatives demonstrate antifungal activity in laboratory settings, with some showing inhibitory effects against common fungal species. However, this research primarily explores chloroacetamide as a potential active treatment rather than its routine use as a preservative in skincare products.

Chloroacetamide is considered an uncommon allergen in skincare formulations. Allergic contact dermatitis to this preservative has been documented in isolated cases, though such reactions appear rare. As with all preservatives, individual sensitivities vary.

How to Use

Chloroacetamide is a behind-the-scenes ingredient incorporated by formulators at specific concentrations to protect products. Consumers do not need to take any special steps; simply use the skincare product as directed. If you have a known sensitivity to preservatives, patch test new products before broad application.

Safety & Precautions

Chloroacetamide is generally well-tolerated in skincare formulations at typical use levels. Allergic contact dermatitis to this preservative is rare but has been documented; discontinue use if irritation or allergic reaction develops.

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